The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway |
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Authors: | Abbott Caroline R Monteiro Mariana Small Caroline J Sajedi Arshia Smith Kirsty L Parkinson James R C Ghatei Mohammad A Bloom Stephen R |
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Affiliation: | Imperial College London, 6th Floor Commonwealth Building, Hammersmith Campus, Du Cane Road, London W12 ONN, UK. |
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Abstract: | The vagus nerve forms a neuro-anatomical link between the gastrointestinal tract and the brain. A number of gastrointestinal hormones, including cholecystokinin and ghrelin, require an intact vagal-brainstem-hypothalamic pathway to affect CNS feeding circuits. We have shown that the effects of peripheral administration of both peptide YY(3-36) (PYY(3-36)) and glucagon-like peptide-1 (GLP-1) on food intake and activation of hypothalamic arcuate feeding neurones are abolished following either bilateral sub-diaphragmatic total truncal vagotomy or brainstem-hypothalamic pathway transectioning in rodents. These findings suggest that the vagal-brainstem-hypothalamic pathway may also play a role in the effects of circulating PYY(3-36) and GLP-1 on food intake. |
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Keywords: | Neural basis of behavior Ingestive behaviors |
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