Inhibition of adherence of Candida albicans by conventional and experimental antifungal drugs |
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| Authors: | V Vuddhakul J G McCormack W K Seow S E Smith Y H Thong |
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| Affiliation: | Department of Child Health, University of Queensland, South Brisbane, Australia. |
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| Abstract: | We tested the effects of antifungal drugs on adherence of Candida albicans in vitro. Significant reduction of adherence occurred after 2 h incubation with amphotericin B, nystatin, miconazole, econazole, ketoconazole, chlorohexidine and ICI 195,739. Significant inhibition of candida adherence by 5-fluorocytosine and amorolfin required 18 h incubation. Combinations of amphotericin B with 5-fluorocytosine, miconazole, ICI 195,739 and amorolfin resulted in synergistic inhibition of adherence. Adherence is an important pathogenic mechanism in candida infections and interference with this process may represent a major component of the mode of action of antifungal drugs. |
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