Protective effect of the antioxidants selenium, vitamin E, and superoxide dismutase on cultured human endothelial cells (ECs) injured by lipid peroxidation

Lipid peroxidation was induced in cultured human ECs with cumene hydroxide and the protective effect of antioxidants (selenium, vitamin E and SOD) on endothelial cell injury by lipid peroxidation was investigated. The results showed that after administration of antioxidants (Se, Vit E and SOD), concentration of LPO in ECs induced by cumene hydroperoxide was reduced markedly while 6-Keto-PGF1 alpha content in the medium was increased and cell injury was alleviated. These results indicate that through the protective effect on ECs against lipid peroxidation, antioxidants (Se, Vit E and SOD) might play an important role in retarding the process of atherogenesis.