| 基因多态性与利福平对依非韦伦的疗效影响 |
| |
| 引用本文： | 孟现民,;尹康,;董平,;卢洪洲. 基因多态性与利福平对依非韦伦的疗效影响[J]. 世界临床药物, 2014, 0(5): 264-271 |
| |
| 作者姓名： | 孟现民, 尹康, 董平, 卢洪洲 |
| |
| 作者单位： | [1]复旦大学附属公共卫生临床中心药剂科,上海201508; [2]复旦大学药学院临床药学与药事管理教研室,上海201203; [3]复旦大学附属公共卫生临床中心感染科,上海201508 |
| |
| 基金项目： | 十二五国家科技重大专项课题——成人艾滋病适宜治疗策略研究与应用（2012ZX10001003） |
| |
| 摘 要： | 依非韦伦（efavirenz）是中国HIV-1感染者广泛使用的一线抗HIV-1治疗药物。该药的临床标准用量来源于以白种人为主的临床试验,考虑到人种的差异、病理生理及合并用药的不同等对依非韦伦药物动力学的影响,标准剂量的依非韦伦并不适合所有的患者。本文综述依非韦伦血药浓度与其不良反应和疗效的相关性,依非韦伦相关代谢酶的基因多态性、利福平对其血药浓度的影响,并总结了有关中国HIV-1感染者使用依非韦伦的相关研究等,希望为临床及科研工作者提供参考。
|
| 关 键 词： | 基因多态性 利福平 依非韦伦 HIV-1 血药浓度 疗效 |
Effects of genetic polymorphism and rifampicin to efavirenz efficacy in HIV-1 infected patients |
| |
| Affiliation: | MENG Xian-min, YIN Kang, DONG Ping, LU Hong-zhou (1. Department of Pharmacy, Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508; 2. Department of Clinical Pharmacy and Pharmaceutical Administration, School of Pharmacy, Fudan University, Shanghai 201203 3. Department of Infectious Disease, Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, China) |
| |
| Abstract: | Efavirenz is a first-line anti-HIV treatment drug and widely used in Chinese HIV-1 infected patients. The recommended standard dose of efavirenz is derived from clinical trials given priority to with Caucasian. The same dosage is not suitable for all patients considering the differences of race, pathology, physiology and drug combination, which affect the pharmacokinetic of efavirenz. This article reviews the relationship of efavirenz plasma concentration with adverse reactions and efficacy. The effect of genetic polymorphisms existing in related genes and rifampicin on efavirenz plasma concentration in Chinese HIV-1 infected patients are described as well. |
| |
| Keywords: | genetic polymorphism rifampicin efavirenz HIV-1 plasma concentration efficacy |
| 本文献已被 维普 等数据库收录！ |
|
