| 新型动脉微栓滤器一体化氧合器在先心病患儿体外循环术中的应用研究 |
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| 引用本文： | 刘晋萍,崔勇丽,吉冰洋,冯正义,赵举,龙村,李守军,王旭,晏馥霞,胡盛寿.新型动脉微栓滤器一体化氧合器在先心病患儿体外循环术中的应用研究[J].中国分子心脏病学杂志,2014(1):789-791. |
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| 作者姓名： | 刘晋萍 崔勇丽 吉冰洋 冯正义 赵举 龙村 李守军 王旭 晏馥霞 胡盛寿 |
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| 作者单位： | [1]中国医学科学院北京协和医学院国家心血管病中心心血管疾病国家重点实验室阜外心血管病医院体外循环科,北京市100037 [2]中国医学科学院北京协和医学院国家心血管病中心心血管疾病国家重点实验室阜外心血管病医院心外科,北京市100037 [3]中国医学科学院北京协和医学院国家心血管病中心心血管疾病国家重点实验室阜外心血管病医院麻醉科,北京市100037 |
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| 基金项目： | 首都临床特色应用研究项目（课题编号Z131107002213172,属北京市科委） |
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| 摘 要： | 目的旨在初步评估新型动脉微栓滤器一体化氧合器(ALF-MO)在先心病患儿体外循环(CPB)中应用的临床效果。方法自2012年10月至2013年7月,共有44名行心脏直视手术的患儿纳入本研究,其中试验组(n=22)患儿采用含ALF-MO的CPB管路;对照组(n=22)患儿采用常规独立动脉微栓滤器(ALF)的CPB管路。对比研究两组患儿在围CPB期的悬浮红细胞(PRBC)用量、血气变化和术后早期的恢复情况。结果试验组患儿CPB中的预充量明显少于对照组预充量(P0.05)。试验组总PRBC用量显著少于对照组(P0.001)。试验组患儿在CPB30min时的血红蛋白浓度均明显高于对照组(P0.05),代谢缓冲碱BE值明显高于对照组(P0.05);其他时点的各项血气指标两组间均无显著性差异(P0.05)。两组患儿气管插管时间和ICU停留时间比较无统计学差异(P0.05),术后均无死亡,无中枢视神经系统并发症发生。结论应用ALF-MO在先心病患儿CPB中应用是安全可靠的,同时为实施节约用血和改善患儿预后起到积极的推进作用。
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| 关 键 词： | 动脉微栓滤器一体化氧合器 体外循环 先天性心脏病 |
Clinical Evaluation of the Membrane Oxygenator with Integrated Arterial Line Filter during Cardiopulmonary Bypass in infants |
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| LIU Jin-ping,CUI Yong-li,JI Bing-yang,FENG Zheng-yi,ZHAO Ju,LONG Cun,LI Shou-jun,WANG Xu,YANG Fu-xia,HU Sheng-shou.Clinical Evaluation of the Membrane Oxygenator with Integrated Arterial Line Filter during Cardiopulmonary Bypass in infants[J].Molecular Cardiology of China,2014(1):789-791. |
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| Authors: | LIU Jin-ping CUI Yong-li JI Bing-yang FENG Zheng-yi ZHAO Ju LONG Cun LI Shou-jun WANG Xu YANG Fu-xia HU Sheng-shou |
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| Institution: | .( The Deparlment of Cardiopulmonary Bypass, Cardiac surgery and Annesthesiology, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Acad of Med Sci, Peking Union Med CoIL Beijing 100037, China) |
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| Abstract: | Objective The purpose of this study was to touch on the clinical observation of oxygenator with integral arterial filter in pediatric patienls with congenital heart disease （CHD） under cardiac operation. Methods Forty-four CHD patients were involved in this study from October 2012 to July 2013.These patients were randomly assigned to two groups： integral arterial filter group （experimental group, n=22）, and separated arterial filter （control group, n=22）. The red blood cell usage, blood gas analysis during operation, and the early outcome after surgery were compared between the two groups. Results The prime volume in the experimental group was significantly higher than that of the control group （P〈0.05）.There were fifteen patients in experimental group underwent operation without transfusion, whereas only two patients in control groups were free from transfusion, the usage of RBC in experimental group was decreased significantly （p〈0.001）. The hemoglobin level in the experimental group at CPB 30mins and before weaning CPB were all significant lower than that of before CPB, but there were no significant differences （p〉0.05） between two groups in Blood gas analysis during operation, mechanical ventilation time, ICU-stay time, CNS complications and mortality. Conclusion It is safe and reliable to use oxygenator with integral arterial filter in CHD operation, and it made even more effective blood conservation and better outcome. |
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| Keywords: | Membrane Oxygenator with Integrated Arterial Line Filter Cardiopulmonary Bypass Congenital Heart Disease |
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