| HGF 介导 Ox-LDL 诱导的血管平滑肌细胞钙化 |
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| 引用本文： | 颜建云,宋艳,陈燕玲,周芹,陆立鹤.HGF 介导 Ox-LDL 诱导的血管平滑肌细胞钙化[J].中国分子心脏病学杂志,2014(1):822-825. |
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| 作者姓名： | 颜建云 宋艳 陈燕玲 周芹 陆立鹤 |
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| 作者单位： | [1]南方医科大学基础医学院组织胚胎学教研室,广州市510515 [2]中山大学中山医学院病理生理学教研室,广州市510080 [3]中山大学附属第一医院麻醉科,广州市510080 |
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| 基金项目： | 国家自然科学基金项目（81000124）高校基本科研业务费“中山大学青年教师培育计划”（11ykpy8）教育部留学回国人员科研启动基金资助项目 |
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| 摘 要： | 目的研究肝细胞生成因子（hepatocyte growth factor,HGF）在氧化型低密度脂蛋白（oxidized low density lipoprotein，Ox-LDL）诱导的血管平滑肌细胞钙化中的作用。方法本研究采用细胞钙化体外模型，检测HGF的浓度和细胞钙化程度。结果Ox-LDL能促进血管平滑肌细胞钙化，同时上调HGF的表达水平。抑制HGF能减轻Ox-LDL诱导的细胞钙化。结论HGF参与了Ox-LDL诱导的血管平滑肌细胞钙化。
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| 关 键 词： | 血管钙化 氧化型低密度脂蛋白 肝细胞生长因子 血管平滑肌细胞 |
HGF Mediates Ox-LDL-induced Vascular Smooth Muscle Cell Calcification |
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| YAN Jian-yun,SONG Yan,CHEN Yan-ling,ZHOU Qin,LU Li-he.HGF Mediates Ox-LDL-induced Vascular Smooth Muscle Cell Calcification[J].Molecular Cardiology of China,2014(1):822-825. |
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| Authors: | YAN Jian-yun SONG Yan CHEN Yan-ling ZHOU Qin LU Li-he |
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| Institution: | ,( Department of Histology and Embryology, Southern Medical University, 2Department of Pathophysiology, Zhongshan Medical School Sun Yat-Sen University, 3Department of Anesthesiology, The first affiliated Hospital Sun Yat-Sen University, Corresponding author.＂ Lihe Lu, E-mail.＂ lulihe@mail.sysu.edu.cn) |
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| Abstract: | Objective To study the role of HGF in Ox-LDL-induced vascular smooth muscle cell calcification. Methods In vitro model of cell calcification was used in this study. HGF level and calcification were measured by ELISA and alizarin red staining. Results We found that Ox-LDL accelerated vascular smooth muscle cell calcification and up-regulated the expression level of HGF. Inhibition of HGF attenuated Ox-LDL-induccd cell calcification. Conclusion These findings suggest that HGF is involved in Ox-LDL-induced vascular smooth muscle cell calcification. |
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| Keywords: | Vascular Calcification Oxidized Low Density Lipoprotein Hepatocyte Growth Factor Vascular Smooth Muscle Cells |
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