Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation |
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Institution: | 1. Dept of Surgery, University of Pittsburgh Health Science Center, Pittsburg, PA 15213, USA;2. Dept of Pathology, University of Pittsburgh Health Science Center, Pittsburgh, PA 15213, USA;3. Dept of Pediatrics, University of Pittsburgh Health Sciences Center, Pittsburgh, PA 15213, USA |
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Abstract: | On line of thought in organ transplantation feels that immunosuppressive drugs can lead to tolerance induction by allowing a previously unrecognized common mechanism of cell migration and microchimerism to occur perist, and in some cases, become drug independent. It has been recognized that there is a spectrum of susceptibility of different organs to cellular rejection and that the variable ability of these organs to induce donor-specific nonreactivity reflects their comparative content of migratory leukocytes. Here, Thomas Starzl and colleagues discuss how many of the enigmas of transplantation immunology can be explained by this chimerism. |
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