Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes |
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| Affiliation: | 1. Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People''s Republic of China;2. Division of Hematology;3. Central Laboratory, Liaocheng People''s Hospital, Liaocheng, Shandong, People''s Republic of China;1. Department of Ophthalmology, Ophtha Lab at St. Franziskus-Hospital, Muenster, Germany;2. Department of Pediatric Rheumatology and Immunology, University Hospital Muenster, Germany;3. Department of Ophthalmology, University of Duisburg-Essen, Germany |
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| Abstract: | Leukocyte recruitment from the blood circulation into tissue is essential for effective immune responses, and is, consequently, carefully regulated. In this article Yoshiya Tanaka and co-workers describe a model in which proteoglycans on the luminal surface of endothelium capture pro-adhesive cytokines. These cytokines provide the adhesion-inducing signal to particular leukocyte subsets which initiates their transmigration. |
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