Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes |
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| Affiliation: | 1. Division of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland;2. Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan;3. Department of Medical Biochemistry, University of Antwerp, Antwerp, Belgium;1. Resident, Department of Plastic and Reconstructive Surgery, Hotel Dieu de France Hospital, Beirut, Lebanon;2. Resident, Department of Plastic and Reconstructive Surgery, Hotel Dieu de France Hospital, Beirut, Lebanon;3. Assistant Professor, Department of Plastic and Reconstructive Surgery, Hotel Dieu de France Hospital, Beirut, Lebanon;4. Department Head, Department of Plastic and Reconstructive Surgery, Hotel Dieu de France Hospital, Beirut, Lebanon;1. The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3F Kanagawa-ken Sogo Iryo Kaikan, 3-1 Fujimi-cho, Naka-ku, Yokohama-city, Kanagawa 231 0037, Japan;2. Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa 216 8511, Japan;3. Department of Endocrinology and Metabolism, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama-city, Kanagawa 236 0004, Japan;1. Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel;1. Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK;2. AstraZeneca, Alderley Edge, Cheshire, UK;3. Inserm, U1016, Institut Cochin, Paris, France;4. CNRS, UMR8104, Paris, France;5. Université Paris Descartes, Sorbonne Paris cité, Paris, France;6. Department of Genetic Medicine & Development, Faculty of Medicine, University of Geneva, Geneva, Switzerland;7. Cambridge Institute for Medical Research, Addenbrooke''s Hospital, Cambridge, UK;8. University Paris Diderot-Paris 7-Unit of Functional and Adaptive Biology (BFA) EAC 7059C NRS, France;1. Laboratory of Pharmaceutical Chemistry, 1050 Brussels, Belgium;2. Analytical Platform, Faculty of Pharmacy, Université Libre de Bruxelles, 1050 Brussels, Belgium;3. Laboratory of Experimental Medicine, CHU de Charleroi, A. Vésale Hospital, Université Libre de Bruxelles, 6110 Montigny-le-Tilleul, Belgium;4. Department of Chemistry, Division of Biochemistry, University of Natural Resources and Life Sciences (BOKU), 1180 Vienna, Austria;5. Torrey Pines Pharmaceuticals, Del Mar, California 92014;6. Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, California 92037;7. Laboratory of Cellular Biology, 5000 Namur, Belgium;8. Technology Transfer Office, University of Namur, 5000 Namur, Belgium;9. Institute of Interdisciplinary Research, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Faculty of Sciences, Université Libre de Bruxelles, 6041 Gosselies, Belgium;10. Laboratory of Molecular Parasitology, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Faculty of Sciences, Université Libre de Bruxelles, 6041 Gosselies, Belgium |
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| Abstract: | Programmed cell death (apoptosis) is triggered in immature thymocytes and T-cell hybridomas by signalling via the CD3-T-cell receptor pathway. In this paper, Dieter Kabelitz and colleagues catalogue the recently accumulating evidence that apaptosis can also be initiated in mature peripheral T cells this may constitute an important aspect of cellular immune regulation. |
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