A role for a pre-T-cell receptor in T-cell development |
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| Affiliation: | 1. Department of Gynecology, Ningbo Municipal Hospital of Traditional Chinese Medicine, Ningbo, 315010, China;2. College of Traditional Chinese Medicine, Zhejiang Pharmaceutical College, Ningbo, 315503, China;1. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy;2. IRCCS-Humanitas Clinical and Research Center, Rozzano-Milan, Italy;3. Department of Molecular Medicine, Istituto Pasteur-Fondazione Cenci Bolognetti, “Sapienza” University of Rome, Italy;1. Department of Medicine, Baylor College of Medicine, Houston, TX, USA;2. Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children’s Hospital, Houston Methodist Hospital, Houston, TX, USA;3. Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA;4. Department of Otolaryngology, Baylor College of Medicine, Houston, TX, USA;1. Department of Pediatrics, Baylor College of Medicine, Houston, TX 77025, USA;2. Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77025, USA;3. Center for Human Immunobiology, Texas Children’s Hospital, Houston, TX 77030, USA |
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| Abstract: | Expression of a productive T-cell receptor (TCR) β gene has profound consequences for T-cell development, preceding an increase in thymocyte number, appearance of CD4 and CD8 coreceptors and suppression of further TCRβ-gene rearrangement. Here Marcus Groettrup and Harald von Boehmer discuss the data obtained in various experimental models and describe a novel signal transducing receptor complex on pre-T cells, which may regulate the TCRβ-induced developmental changes. |
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