胃癌不同分化程度与PTEN表达缺失的相关性

目的：探讨磷酸酶基因（PTEN）表达缺失情况与胃癌分化程度的关系。方法：通过检测52例经病理证实为胃癌的手术标本或胃镜检查活检标本中PTEN的表达情况,并与浅表性胃炎和正常无病变的胃黏膜活检标本（各20例）比较。结果：浅表性胃炎组、正常胃黏膜组所有标本中PTEN均有高度阳性（＋＋＋）表达,两组无明显差异（P〉0.05）;低分化胃癌组、中分化胃癌组、高分化胃癌组与浅表性胃炎组或正常胃黏膜组比较,随着胃癌分化程度的降低,PTEN的表达逐渐减弱,组间差异经统计学分析有显著性意义（P〈0.05）。结论：PTEN的表达情况与胃癌的分化程度密切相关,胃癌组织学分化越差,PTEN的表达缺失越明显。

Relationship Between the PTEN Protein Expression Deletion and Differentiation Grades in Patients with Gastric Cancer

Objective To investigate the relationship between PTEN gene expression and gastric cancer histologic differentiation.Methods PTEN expression was studied with immuno-histochemistry technique in 52 specimens of pathologically confirmed gastric cancer,20 biopsy specimens of superficial gastritis and 20 biopsy specimens of normal gastric mucosa.Results Strong positive staining of PTEN(+++) was found in all samples from superficial gastritis group and normal group,without significant difference between the 2 gro...