牛磺酸对高碘仔鼠脑发育和学习能力的影响

目的：探讨牛磺酸对高碘仔鼠脑发育和智力的影响。方法：将动物随机分为3组：适碘组、高碘组、高碘＋0．6％牛磺酸组（简称牛磺酸组），各组亲代小鼠饲养3个月后雌雄交配，测定各组30日龄仔鼠的学习记忆能力及脑组织相关生化指标。结果：高碘组30日龄仔鼠脑蛋白质和DNA含量下降，牛磺酸组与适碘组差异无显性：高碘组30日龄仔鼠脑海马组织乙酰胆碱酯酶活性比适碘组和牛磺酸组明显升高，乙酸胆碱含量下降。与适碘组相比，牛碘酸组乙酰胆碱酯酶活性无统计学差异，而乙酰胆碱含量上升。结论：牛磺酸能拮抗高碘所致的发育障碍。

Effects of taurine on brain development and learning ability in filial mice fed with high iodine

Objective To observe the effects of taurine on brain development and learning ability in filial mice fed with high iodine. Methods Mice were divided into three groups, the first one fed with adequate dose of iodine, the second with high dose iodine, and the third with high dose iodine plus 0 6% taurine All the male and female mice were mated three months after treatment Relevant biochemical indicators in the brain tissues and their memory and learning ability were measured for their offsprings with 30 days old in the three groups. Results Brain contents of protein and DNA reduced in the high dose iodine group, and there was no significant difference in them between groups with taurine and adequate dose iodine 30 days after their birth Activity of acetylcholine esterase (ACHE) increased and content of acetylcholine decreased in the hippocampus of filial mice at age of 30 days with high dose iodine Content of acetylcholine increased in the filial mice with high dose iodine plus taurine than that with adequate dose iodine, but there was no statistically significant difference in ACHE between them. Conclusion Taurine could antagonize disturbance of brain development in filial mice caused by high dose iodine