西施泰膀胱灌注联合膀胱黏膜电灼治疗腺性膀胱炎的临床研究

目的 观察西施泰膀胱灌注联合膀胱黏膜电灼治疗腺性膀胱炎的疗效.方法 腺性膀胱炎患者90例,随机分成试验组和对照组各45例.两组患者行膀胱黏膜电灼术后5 d拔除尿管：试验组术后第7 d用西施泰40 mg/（50mL）行第一次膀胱灌注,其后1次/周,共4次;对照组不做膀胱灌注.所有患者均于术后3月评价治疗效果.结果 试验组38例膀胱镜检查膀胱黏膜正常或基本正常,35例治愈,2例缓解,1例未愈;7例膀胱镜检查病变残留或新发（滤泡样水肿型或乳头瘤型）,再次电灼并西施泰膀胱灌注治疗,4例治愈,1例缓解,2例未愈.试验组总治愈率86.7%,总有效率93.3%.对照组膀胱镜检查31例膀胱黏膜正常或基本正常,26例治愈,2例缓解,3例未愈;14例膀胱镜检查病变残留或新发（滤泡样水肿型或红润型）,再次电灼治疗,6例治愈,1例缓解,7例未愈.对照组总治愈率71.1%,总有效率77.8%.2组间比较差异有统计学意义（P〈0.05）.结论 西施泰膀胱灌注联合膀胱黏膜电灼治疗腺性膀胱炎疗效显著,值得推广.

Clinical research of transurethral electric coagulation combined with bladder instillation of cystistat to treat cystitis glandularis

Objective To observe the efficacy of bladder instillation of cystistat in the treatment of cystitis glandularis after transurethral electric coagulation.Methods 90 patients with cystitis glandularis were randomly divided into two groups.For the experimental group,patients received transurethral electric coagulation and the catheter was removed 5 days after the operation.And then,on the 7th day after the operation,the patients received bladder instillation with sodium hyaluronate(40 mg/50 mL).After that,the patients received instillation once a week for 4 weeks.The control group underwent the same treatment except for bladder instillation.The clinical results of all patients were evaluated after 3 months.Results Of the experimental group,35 patients were cured,1 was not cured,and 2 patients’ symptoms were improved.The other 7 patients with residual or new lesions(folliculoid or papilloma type) received another transurethral electric coagulation and bladder instillation.After that,4 patients were cured,2 not cured,and 1 patient’s symptoms were improved.The cure rate of the experimental group was 86.7% and the efficacy rate was 93.3%.Of the control group,26 patients were cured,3 not cured,and 2 patients’ symptoms were improved.14 patients with residual or new lesions(folliculoid or papilloma type) were treated with transurethral electric coagulation again.After that,6 patients were cured,7 not cured,and 1 patient’s symptoms were improved.The cure rate of the control group was 71.7% and the efficacy rate was 77.8%.There was statistical difference between the two groups(P<0.05).Conclusion Transurethral electric coagulation combined with bladder instillation of sodium hyaluronate is effective for cystitis glandularis.