| 年龄对丙泊酚药效学的影响 |
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| 引用本文： | 徐辉,张马忠,张跃.年龄对丙泊酚药效学的影响[J].医学理论与实践,2004,17(9):1026-1028. |
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| 作者姓名： | 徐辉 张马忠 张跃 |
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| 作者单位： | 1. 南京医科大学附属淮安市第一人民医院麻醉科,江苏省淮安市,223300
2. 上海第二医科大学附属仁济医院麻醉科 |
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| 摘 要： | 目的 :确定以MAP作为效应指标时 ,年龄对丙泊酚效应位的消除速率常数 (ke0 )和 5 0 %最大效应的效应位浓度 (EC50 )的影响。方法 :15例病人按年龄分为老年组 (>6 5岁 ,n =8)和青壮年组 (<6 5岁 ,n =7) ,分别持续输注丙泊酚 6 0mL/h和 75mL/h直至病人意识消失。持续监测MAP直至两者恢复至用药前 95 %以上水平。效应室消除速率常数ke0根据Hill曲线计算。结果 :老年人和青壮年人的EC50 分别为 2 4 9μg/mL和5 32 μg/mL(P <0 0 5 ) ;ke0分别是 0 14 5min-1和 0 193min-1(P <0 0 5 )。结论 :年龄显著影响ke0和EC50 。持续输注丙泊酚对老年病人MAP的影响大且恢复缓慢
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| 关 键 词： | 二异丙酚 效应位 ke0 EC50 |
| 修稿时间： | 2004年3月26日 |
The Influence of Age on Pharmacodynamics of Propofol |
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| XU Hui,ZHANG Mazhong,ZhANG Yue.The Influence of Age on Pharmacodynamics of Propofol[J].The Journal of Medical Theory and Practice,2004,17(9):1026-1028. |
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| Authors: | XU Hui ZHANG Mazhong ZhANG Yue |
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| Institution: | XU Hui~*,ZHANG Mazhong,ZhANG Yue.~* Department of Anesthesiology,The First People's Hospital of Huaian,Jiangsu Province 223300 |
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| Abstract: | Objective: To determine the influence of age on ke0 and EC_(50) of propofol when MAP was regarded as the index of effect. Methods: 15 patients were divided into the young and middle-aged group (<65years old, n=7) and the elderly group (>years old, n=8), received continuous infusion of propofol 75mL/h and 60mL/h respectively up to loss of consciousness. MAP was recorded continuously from start of infusion to restore MAP to 95% of premedication. ke0 and EC_(50) were estimated by fitting a Hill curve. Results: The EC_(50) of MAP were 2.49μg/mL and 5.32μg/mL in elderly group and young and middle-aged group respectively (P<0.05). The ke0s were 0.145min~(-1) and 0.193min~(-1) in elderly group and young and middle-aged group respectively (P<0.05).Conclusion: Age has significant effect on ke0 and EC_(50) of MAP. Continuous infusion of propofol may decrease MAP to a greater degree and recover slowly in elderly. |
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| Keywords: | Propofol Effect-site ke0 EC_(50) |
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