脾炎症性肌纤维母细胞瘤肝转移1例报告并文献复习

目的：探讨炎性肌纤维母细胞瘤的临床病理特点、鉴别诊断及预后。方法：观察分析1例脾炎症性肌纤维母细胞瘤术后4 a肝转移病例的临床病理特点及免疫表型,并对相关文献复习。结果：瘤细胞梭形,呈束状、旋涡状或席纹状排列,间质大量炎症细胞弥漫浸润,脾肿瘤细胞形态温和无明显异型,肝转移灶瘤细胞轻度异型,局部呈浸润性生长;免疫组化Vimentin、SMA阳性,ALK阴性。结论：炎性肌纤维母细胞瘤是少见肿瘤,诊断须依赖病理形态及免疫组化,大多预后较好，出现异型提示预后不良。

Inflammatory myofibroblastic Tumour of Spleen with Liver Metastasis: A Case Report and Review of Literature

Objective..To investigate the clinicopathologic characteristics.differential diagnosis and prognosis of inflammatory myofibroblastic tumour （IMT）. Methods ：A case of spleen IMT with liver metastasis after spleen tumor excision for 4 years was observed by clinical data, light microscopy and immunohistochemistry, and the related literature was reviewed. Results：The tumour was composed of spindle cells with a great quantity of acute and chronic inflammatory cells in stroma, which showed cellular fascicles, whorled structure or storiform growth pattern, the cells of spleen tumour exhibited benign and no cytological atypia, while the liver metastasizing tumour cells exhibited mild cytological atypia, focally infiltrated margins; Immunohistochemically, the tumor cells were positive for Vimentin and SMA, and negative for ALK. Conclusion：IMT is an uncommon tumour. The diagnosis depends on morphological features and immunohistochemistry. Most of them have a good prognosis and cytological atypia might suggest poor prognosis.