18F-PET-CT显像在肺癌纵隔淋巴结转移中临床应用价值

目的：探讨PET-CT显像在判断肺癌纵隔淋巴结转移中的临床应用价值。方法：回顾性分析67例肺癌患者在手术前CT、PET、PET-CT显像结果。67例肺癌患者均经手术治疗，手术共取出不同大小淋巴结319枚，其中转移淋巴结68枚，且所有取出淋巴结均经病理证实。以病理结果作为标准，分析CT、PET、PET-CT检查结果的准确性，分别计算CT、PET、PET-CT诊断的准确率、灵敏度、特异性、阳性预测值和阴性预测值等指标，并对CT、PET、PET-CT的诊断准确率进行比较。结果：CT、PET、PET-CT判断肺癌纵隔淋巴结转移的分别为74.6%、80.9%、88.7%；61.8%、80.9%、86.8%；78.1%、79.4%、89.2%；43.3%、53.4%、68.6%；88.3%、93.4%、96.1%。CT诊断纵隔淋巴结的准确率低于PET，差异无统计学意义，PET-CT诊断的准确率高于PET，P＜0.05。结论：PET-CT显像对判断肺癌淋巴结转移的准确率高。

18F-FDG PET-CT in detecting lymph nodes metastasis of lung cancer

Objective: To evaluate the clinical value of PET-CT in judging mediastinal lymph nodes metastasis of lung cancer.Methods: A retrospective review of the CT,PET and PET-CT findings of 67 patients was performed.In operations,319 mediastinal lymph nodes samples were acquired by resection,and 68 metastasis lymph nodes were proved by pathology.The accuracy,sensitivity,specificity,positive predictive value(PPV) and negative predictive value(NPV) of CT,PET and PET-CT were determined.Results: In detecting mediastinal lymph node metastasis,the accuracy of CT,PET and PET-CT scans was 74.6%,80.9% and 88.7%;the sensitivity of them was 61.8%,80.9% and 86.8%;the specificity was 78.1%,79.4% and 89.2%;the PPV was 43.3%,53.4% and 68.6%;the NPV was 88.3%,93.4% and 96.1%.The accuracy of PET-CT scans was significantly better than that of PET or CT scans in determining mediastinal lymph node metastasis(P<0.01).Conclusion: PET-CT is more accurate than PET or CT.