The use of albumin microspheres in the treatment of carrageenan-induced inflammation in the rat. |
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| Authors: | D A Lewis W N Field K Hayes H O Alpar |
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| Institution: | Pharmaceutical Sciences Institute, Aston University, Birmingham, UK. |
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| Abstract: | Free hydrocortisone, hydrocortisone incorporated into microspheres and empty microspheres have been administered orally to rats with carrageenan-induced hindpaw inflammation. Hydrocortisone administered in particles was effective at a lower dose than free steroid in reducing inflammation. Inflammatory exudates were able to release steroid from the microspheres by proteolytic degradation. |
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