Experimental study on spinal cord injury treated by embryonic spinal cord transplantation and greater omental transposition

Objective: To observe the clinical efficacy of the embryonic spinal cellular transplantation and greater omentaltranspesition for treatment of the spinal cord injury in 24 mongrel dogs. Methods: 24 adult mongrel dogs, weighing 10 ～ 13kg, without male and female limit, were employed in this experimental study and randomly divided into 4 groups:①simple injury group(group A) ;②greater omental transposition group (group B) ;③embryonic spinal cellular transplantation group (group C) ;④em-bryonic spinal cellular transplantation and greater omental transposition group (group D). Each group consisted of 6 dogs. SEP(somatosensory evoked potential) and MEP (motor evoked potential) of the spinal cord were examed prior to the spinal cord injuryand 2 months after the treatment to observe the changes of the animals‘ behavior. All dogs were killed 2 months after surgery andthe spinal cord sections were obtained from TI2 to LI level for pathological analysis and observation under the electron microscope.Re.lilts: There was an obvious difference in the spinal sematosensory evoked potential and the motor evoked potential between thegroup D.and the other three groups (group A, B, and C). Recovery of the behavior was noted. The spinal cells had survived fortwo months following the transplantation. Conclusion: Transplantation of the embryonic spinal cell and greater omentum for treat-ment of the spinal cord injury in dogs can gain a better outcome than the other groups in behavior and spinal somatosensory andmotor evoked potential, but the further study is still essential to confirm its clinical efficacy.