强直性脊柱炎肌腱端炎与临床及实验室炎性指标的关系

目的 探讨强直性脊柱炎（AS）患者肌腱端炎与有关临床及实验室指标的相关性。方法 触压66个肌腱附着点，计算肌腱端指数，探讨AS患者肌腱端炎的严重程度与临床评价指标BathAS疾病活动指数（BASDAI）、Bath AS功能指数（BASFI）、Bath AS测量指数（BASMI）、脊柱痛、夜间痛、脊柱炎症、整体关节肿胀指数、生活质量及实验室炎性指标血沉（ESR）、C反应蛋白（CRP）的相关性。结果 共纳入78例AS患者，均处于疾病活动期，多数患者（98．7％）有肌腱端炎，肌腱端炎好发于骶髂关节、腰椎突起、颈椎突起、坐骨结节及跟腱附着点。双变量相关分析显示肌腱端炎与疾病活动性，脊柱痛、脊柱炎症、功能状况、夜间痛、AS测量指数及扩胸度相关，与ESR、CRP无关。结论 肌腱端指数可以反映AS患者疾病活动性，是评价疾病活动性的有效临床方法。

Relationship between the Severity of Enthesitis and Clinical and Laboratory Parameters in Patients with Ankylosing Spondylitis

Objective To assess the relationship between the severity of enthesitis and outcome of measurement indices, clinical and laboratory parameters in patients with ankylosing spondylitis （AS）. Methods Sixtysix entherent tender points were assessed. The severity of enthesitis was assessed in AS patients in active phase by using Enthesitis Index, and correlated with clinical parameters of disease, which included the Bath AS disease activity index （BASDAI）, Bath AS functional index （BASFI）, Bath AS metrology index （BASMI）, night pain, ESR, CRP and quality of life. Results A total of 78 patients with ankylosing spondylitis were recruited. Most of them had enthesitis. After controlling for the correlative factors, it was found that the severity of enthesitis highly correlated with disease activity, rachiodynia, functional disability, BASMI, physical health and mental health. There was no correlation in indice of ESR and CRP. Conclusion The enthesis index strongly correlated with disease activity, and could be used as a useful clinical index for assessing disease activity in AS.