洗涤剂椰油酰胺丙基甜菜碱过敏

目的观察洗涤剂椰油酰胺丙基甜菜碱（CAPB）在北京协和医院变态反应科接触性皮炎患者中的斑贴试验阳性率。方法对本科门诊湿疹患者进行常见的10种接触性过敏原的斑贴试验：香料混合物、柳硫汞、咪唑烷基脲、甲醛、凯松CG、对苯二胺、硫酸镍、重铬酸钾、氯化钴和CAPB，观察CAPB的阳性率。结果在进行斑贴试验的562例湿疹患者中。CAPB阳性5例，其中4例为全身皮炎，1例为面部皮炎。5例进行相关化妆品或洗涤用品的斑贴试验均有阳性反应。结论本院接触性皮炎患者中的CAPB阳性率低于其他报道，但考虑到洗涤剂的广泛应用,应在怀疑化妆品过敏引起的湿疹皮炎患者中常规进行CAPB斑贴试验。

Allergic Contact Dermatitis induced by Cocamidopropyl Betaine

Objective To evaluate the prevalence of cocamidopropyl betaine （CAPB） sensitization in contact dermatitis patients by patch test in Peking Union Medical College Hospital. Methods Totally 562 consecutive patients with suspected allergic contact dermatitis were patch tested with Fragrant Mix, thimerosal, Imidazolidinyl Urea, Formaldehyde, 1 ＋Me-Isothiazolinone, P-Phenylenediamine, nickel sulphate, potassium dichromate, cobalt chloride, and CAPB. Results Five patients （0.9%） had a positive reaction to CAPB. Among them, 4 were shown systemic dermatitis, 1 was attached by face dermatitis （eyelids and cheeks）. All patients were considered clinical relevant since the cosmetics products were patch tested with positive results. Conclusions The rate of CAPB sensitization in our study is lower than previously reported. CAPB should be tested in contact dermatitis patients with suspected cosmetic dermatitis considering its wide usage in cosmetics.