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| 和络舒肝胶囊对肝损伤防治作用的实验研究 | |
| 引用本文： | 杨文彬,柴秋彦,李百强,史向华,周秀梅,杨世英. 和络舒肝胶囊对肝损伤防治作用的实验研究[J]. 山西中医, 2002, 18(3): 49-51 |
| 作者姓名： | 杨文彬 柴秋彦 李百强 史向华 周秀梅 杨世英 |
| 作者单位： | 1. 山西省医药研究所 2. 山西省中医药研究院 3. 山西黄河中药有限公司 |
| 摘 要： | 目的：观察和络舒肝胶囊对急慢性肝炎致肝损伤的防治作用。方法：采用小鼠ip0.1?l4菜籽油溶液及50mg/kg TAA造成急性肝损伤模型；大鼠背部SC40％CCl4植物油溶液5.0ml/kg，连续6周造成慢性实验性肝损伤、肝硬化病理模型。观察和络舒肝胶囊对模型ALT升高、肝脏病理改变及其胶原蛋白含量的影响。结果：和络舒肝胶囊对急性肝损伤ALT升高有抑制作用，并且能降低慢性实验性肝损伤、肝硬化模型中肝脏的胶原蛋白含量。结论：该药对实验性急慢性肝损伤有较好的防治作用。 |
| 关 键 词： | 肝损伤 和络舒肝胶囊 实验研究 防治作用 |
| 文章编号： | 1000-7156(2002)03-0049-03 |
| 修稿时间： | 2002-03-18 |
Experimental Research on the Effect of Heluoshugan Capsule(和络舒肝胶囊) on Liver Injury |
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| YANG Wen bin,CHAI Qiu yan,LI Bai qiang,et al. Experimental Research on the Effect of Heluoshugan Capsule(和络舒肝胶囊) on Liver Injury[J]. Shanxi Journal of Traditional Chinese Medicine, 2002, 18(3): 49-51 | |
| Authors: | YANG Wen bin CHAI Qiu yan LI Bai qiang et al |
| Abstract: | Objective:To observe the effect of Heluoshugan Capsule(HC) on liver injury caused by hepatitis.Methods:The mouse models of acute liver injury were made by 0.1% CCl 4 and solution of vegetable seeds oil and TAA 50mg/kg ip.The models of chronic liver injury and hepatocirrhosis were made by 40% CCl 4 and solution of plant oil 5.0ml/kg subcutaneously in the back of rats for 6 weeks.The blood ALT?pathological changes of the liver and collagen were observed.Results:Heluohshugan Capsule could control the high ALT in acute liver injury.It could also reduce the liver collagen in chronic liver injury and hepatocirrhosis.Conclusion:Heluoshugan capsule had preventive and therapeutic effect on experimental acute or chronic liver injury. |
| Keywords: | injury of the liver Heluoshugan Capsule experimental research |
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