大鼠补硒后血谷胱甘肽过氧化酶，维生素E和脑脂褐质的变化

采用猪油（Ｌ）或玉米油（Ｍ）加胆固醇饲料诱导大鼠高脂血症模型以含硒量约为３．５ｍｇ／ｋｇ的富硒饲料Ｌａｒｄ－Ｓｅ（Ｌ一Ｓｅ），Ｍａｉｚｅｏｉｌ－Ｓｅ作为干预因素，观察实验性高脂血症大鼠补硒后血液ＧＳＨ－Ｐｘ，ＶＥ和大脑脂褐质（ＬＰＦ）的变化。结果表明，Ｌ－Ｓｅ组的ＧＳＨ－Ｐｘ活性比Ｌ组升高４２．８６％；玉米油是否加硒的两组（Ｍ和Ｍ－Ｓｅ）动物血清ＶＥ浓度均高于Ｌ，Ｍ－Ｓｅ组比Ｍ组升高２４．７７％。但富硒的Ｌ－Ｓｅ组ＶＥ水平比Ｌ组升高近７３％。此外，补硒动物（Ｌ－Ｓｅ和Ｍ－Ｓｅ）的大脑ＬＰＦ明显低于非补硒组。相关分析的结果显示，血Ｓｅ，肝Ｓｅ含量与ＧＳＨ－Ｐｘ呈明显正相关，血硒与血清ＶＥ呈正相关，肝硒与大脑ＬＰＦ呈明显负相关。上述结果提示，富硒饲料对增强高血脂大鼠体内抗氧化能力，减少脂质过氧化作用有效。

EFFECTS OF Se-ENRICHED DIETS ON SERUM VE, BLOOD GSH-PX AND BRAIN LIPOFUSCIN IN HYPERLIPEMIA RATS

The comparative effects of lard and maize oil with or without enriched Se on serum VE, blood GSH-Px and brain lipofuscin (LPF) were investigated in hyperlipidemic rats. 40 male SD rats were divided into two groups and were raised on l0%lard 1.5%cholesterol (L) or 10%maize oil 1.5% cholesterol (M) respectivily. Hyperlipidemia was successfully induced after feeding the above ration for 10 weeks.Then 10 rats continued on L or M diet and other 10 rats fed on Se-enriched diet (L-Se or M-Se,3.5mg/kg Se)in a 10 week period. The results showed that the activity of GSH-Px in L-Se group was 42.68%higher than L group and M-Se group was 24.77% higher than M group. The concentration of serum VE in L-Se group was almost 77%higher than the lard group without Se-enriched, there were significantly higher levels of serum VE in both maize oil with or without Se-enriched(Mand M-Se)groups. The contents of brain lipofuscin in Se-enriched groups (L-Se and M-Se) were decreased significantly compared with non Se-enriched groups(L and M). The data indicated that the Se-enriched diets had the effects of enhancing the antioxidation and reducing the lipid peroxidation in hyperlipidemia rats.