| 慢性乙型肝炎患者血清HBV DNA水平变化及临床意义 |
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| 引用本文： | 金珍婧,迟宝荣.慢性乙型肝炎患者血清HBV DNA水平变化及临床意义[J].吉林大学学报(医学版),2003,29(6):808-809. |
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| 作者姓名： | 金珍婧 迟宝荣 |
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| 作者单位： | 1. 吉林大学第二医院消化内科,吉林,长春130041
2. 吉林大学第一医院消化内科 |
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| 基金项目： | 吉林省计经委资助项目;2000-9; |
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| 摘 要： | 目的 :探讨慢性乙型肝病患者血清 HBV DNA水平变化在慢性乙型肝病发生发展中的作用及临床意义。方法 :采用荧光定量 PCR( FQ- PCR)法检测慢性乙型肝炎 ( CHB)、慢性乙型重型肝炎 ( CSHB)、乙型肝炎性肝硬化 ( HBC)患者血清 HBV DNA含量。结果 :HBV DNA含量随病情加重逐渐下降 ,CSHB组与 CHB、HBC组相比差异具有显著性 ( P<0 .0 1 )。结论 :慢性乙型肝病患者机体存在免疫功能调控失衡 ;动态观察 HBV DNA水平变化有助于判断肝脏病变程度
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| 关 键 词： | 肝炎 乙型 慢性 DNA 病毒 聚合酶链反应 |
| 文章编号： | 1671-587X(2003)06-0808-02 |
| 修稿时间： | 2002年5月27日 |
Change of HBV DNA Level in the Sera of Patients with Chronic Viral Hepatic Disease and its Clinical Significance |
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| JIN Zhen jing ,CHI Bao rong.Change of HBV DNA Level in the Sera of Patients with Chronic Viral Hepatic Disease and its Clinical Significance[J].Journal of Jilin University: Med Ed,2003,29(6):808-809. |
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| Authors: | JIN Zhen jing CHI Bao rong |
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| Institution: | JIN Zhen jing 1,CHI Bao rong 2 |
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| Abstract: | Objective: To observe the change of HBV DNA level in the sera of patients with chronic viral hepatic disease and its clinical significance. Methods:The amount of HBV DNA in the sera of patients with chronic hepatitis B (CHB), chronic severe hepatitis B (CSHB) and hepatic B cirrhosis (HBC) were measured with FQ PCR. Results: The level of HBV DNA in CSHB group was significantly lower than those in CHB and HBC groups ( P <0.01). The bilirubin level in the sera of patients with chronic viral hepatic disease of different clinical types had a inverse relationship with the level of HBV DNA. Conclusion: The patients with chronic viral hepatic disease had an unbalance on the regulation and control of immunologic function. The level of HBV DNA as well as the bilirubin level in the sera of patients can reflect the necrosis degree of liver cells. |
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| Keywords: | Hepatitis B Chronic DNA viral Polymerase chain reaction |
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