Anti-miRNA21 and resveratrol-loaded polysaccharide-based mesoporous silica nanoparticle for synergistic activity in gastric carcinoma |
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| Authors: | Yu Hu Zhehui Wang Yunfeng Qiu Yang Liu |
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| Affiliation: | 1. Department of Pathology, China-Japan Union Hospital of Jilin University, Changchun, China;2. Department of Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun, China |
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| Abstract: | AbstractAnti-miR21 and resveratrol (RSV)-loaded mesoporous silica nanoparticles (MSNs) conjugated with hyaluronic acid (HA) were developed to enhance therapeutic efficacy in gastric carcinoma. The surface conjugation of HA, which acts as a targeting ligand to the overexpressed CD44 receptor on gastric cancer cells, was clearly identified by the presence of a greyish shell on the dark MSNs. Confocal laser-scanning microscopy and flow cytometry analysis showed higher cellular internalisation of HA/RSVmirNP compared to RSVmirNP. In vitro cytotoxicity and apoptosis assays confirmed the superior anticancer effect of the optimised formulation and synergistic effects of anti-miR21 and RSV in gastric cancer cells. Importantly, HA/RSVmirNP showed significant (p?
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| Keywords: | Gastric cancer resveratrol anti-miR21 mesoporous silica nanoparticles cancer targeting |
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