Celecoxib Incorporated Chitosan Microspheres: In Vitro and In Vivo Evaluation |
| |
Authors: | Hetal Thakkar RK Sharma AK Mishra Krishna Chuttani |
| |
Institution: | 1. New Drug Delivery System Laboratory, Pharmacy Department, M.S.University of Baroda, Donor's Plaza, Opp. To University main office, Fatehgunj, 390 002, Vadodara, India;2. Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. S.K. Mazumdar Road, 110 054, Delhi, India |
| |
Abstract: | Recently, considerable interest has been focussed on the use of biodegradable polymers for specialized applications such as controlled release of drug formulations; meanwhile, microsphere drug delivery systems using various kinds of biodegradable polymers have been studied extensively during the past two decades. In the present investigation, it was aimed to prepare microsphere formulations of celecoxib using a natural polymer, chitosan as a carrier for intra-articular administration to extend the retention of the drug in the knee joint. Microsphere formulations were evaluated in vitro for particle size, entrapment efficiency, surface morphology and in vitro drug release. For in vivo studies, 99mTechnetium- labeled glutathione was used as a radiopharmaceutical to demonstrate arthritic lesions by gamma scintigraphy. Evaluation of arthritic lesions post therapy in rats showed a significant difference (P<0.05) in the group treated with celecoxib solution compared to the group treated with celecoxib loaded chitosan microspheres. |
| |
Keywords: | Biodegradable polymers Glutathione Chitosan Celecoxib |
|
|