| 黏附分子-1对鼻息肉中嗜酸性粒细胞聚集及临床预后的意义 |
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| 引用本文： | 周兵,李华斌,韩德民,刘仲燕.黏附分子-1对鼻息肉中嗜酸性粒细胞聚集及临床预后的意义[J].临床耳鼻咽喉头颈外科杂志,2004,18(2):72-73. |
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| 作者姓名： | 周兵 李华斌 韩德民 刘仲燕 |
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| 作者单位： | 1. 首都医科大学附属北京同仁医院耳鼻咽喉-头颈外科,北京市耳鼻咽喉科研究所,北京,100005
2. 江苏省人民医院耳鼻咽喉科 |
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| 摘 要： | 目的 :探讨黏附分子 1(ICAM 1)在鼻息肉中的表达及对嗜酸性粒细胞聚集和临床预后的意义。方法 :采用荧光免疫组织化学法检测 35例慢性鼻窦炎、鼻息肉患者 (鼻息肉组 )的鼻息肉组织及 15例慢性鼻炎患者 (对照组 )的下鼻甲黏膜中ICAM 1的表达并进行定量分析。结果 :鼻息肉组和对照组嗜酸性粒细胞平均计数分别为 (2 8.4± 10 .7)个 /mm2 和 (9.9± 8.6 )个 /mm2 ,ICAM 1相对荧光强度为 115 .9± 82 .4和 2 8.2± 17.1,随鼻息肉严重程度的加重 ,ICAM 1的表达强度逐渐增高。结论 :ICAM 1对鼻息肉中嗜酸性粒细胞的聚集及鼻息肉的预后具有重要的意义 ,抗感染和抗变态反应在鼻息肉的治疗上具有同等的地位
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| 关 键 词： | 鼻息肉 细胞黏附分子 嗜酸性粒细胞 |
| 文章编号： | 1001-1781(2004)02-0072-02 |
| 修稿时间： | 2003年7月10日 |
Role of ICAM-1 in eosinophilia and prognosis of nasal polyps |
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| ZHOU Bing,LI Huabin,HAN Demin,LIU Zhongyan.Role of ICAM-1 in eosinophilia and prognosis of nasal polyps[J].Journal of Clinical Otorhinolaryngology,2004,18(2):72-73. |
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| Authors: | ZHOU Bing LI Huabin HAN Demin LIU Zhongyan |
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| Institution: | Department of Otolaryngology-Head and Neck Surgery, Capital University of Medical Sciences Affiliated Beijing Tongren Hospital,Beijing Institute of Otolaryngology, Beijing, 100005, China. |
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| Abstract: | OBJECTIVE: To investigate the role of adhesion molecule ICAM-1 (Intercellular adhesion molecule-1) in eosinophilia and prognosis of nasal polyps. METHOD: Expression of ICAM-1 were detected and quantified in 35 cases of nasal polyps with fluorescence-immunohistochemistry analysis and its relationships to eosinophilia and prognosis of nasal polyps were evaluated. RESULT: The numbers of eosinophils in nasal polyps and control nasal mucosas were 28.4 +/- 10.7/mm2 and 9.9 +/- 8.6/mm2, and fluorescent densities of ICAM-1 were 115.9 +/- 82.4 and 28.2 +/- 17.1. The expression of ICAM-1 was associated with the heaviness of nasal polyps. CONCLUSION: ICAM-1 may play an important role in the formation and prognosis of nasal polyps. |
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| Keywords: | Nasal polyps Cell adhesino molecules Eosinophilis |
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