食管癌患者血清维生素E水平meta分析

目的 了解食管癌患者血清维生素E水平，为食管癌的防治及病因探索提供参考依据。方法 检索中国知网数据库、万方数据库、PubMed数据库、Web of Science数据库，并辅以手工检索和文献追溯法收集1980年1月-2015年12月公开发表的关于食管癌患者血清维生素E水平的相关文献；采用Stata 12.0软件对纳入的文献进行meta 分析。结果 最终纳入9篇文献（中文文献7篇，英文文献2篇），累计病例组患者358例，对照组人群538例；meta分析结果显示，病例组食管癌患者血清维生素E水平较对照组人群低（SMD=-0.50，95%CI=-0.65~-0.36，P<0.001）；亚组分析结果显示，国家为中国（SMD=-0.50，95%CI=-0.67~-0.33）和其他国家（SMD=-0.51，95%CI=-0.77~-0.25）、对照来源于社区（SMD=-0.54，95%CI=-0.69~-0.39）、样本量>50例（SMD=-0.56，95%CI=-0.71~-0.41）、年龄匹配（SMD=-0.57，95%CI=-0.72~-0.42）、测定方法为高效液相色谱法（SMD=-0.41，95%CI=-0.59~-0.24）和其他方法（SMD=-0.67，95%CI=-0.91~-0.43）的研究中病例组食管癌患者血清维生素E水平均低于对照组人群（均P<0.001）；敏感性分析和发表偏倚检验结果显示，本研究meta分析结果稳定，且不存在发表偏倚。结论 食管癌患者血清维生素E水平较低。

Serum vitamin E level in esophageal cancer patients: a meta-analysis

Objective To explore the association between esophageal cancer and serum vitamin E level and to provide evidences for researches and prevention of esophageal cancer.Methods Case-control studies on esophageal cancer and serum vitamin E level published from January 1980 to December 2015 were searched through China National Knowledge Infrastructure,Wanfang Database,PubMed,and Web of Science.Meta-analysis was performed with Stata 12.0.Results A total of 9 literatures (7 in Chinese and 2 in English),involving in 358 esophageal cancer cases and 538 controls,were included in the meta-analysis.The meta-analysis showed that the serum vitamin E level of esophageal cancer cases was lower than that of the controls (standardized mean difference[SMD]=-0.50,95% confidence interval[95%CI]=-0.65-0.36,P<0.001).Subgroup analysis found that the serum vitamin E levels of the esophageal cancer cases were lower than those of the controls for the studies conducted in China (SMD=-0.50,95%CI=-0.67-0.33) and in United States (SMD=-0.51,95%CI=-0.77-0.25),with the controls selected from communities (SMD=-0.54,95%CI=-0.69-0.39),with the sample size of larger than 50 (SMD=-0.56,95%CI=-0.71-0.41),with age-matched controls (SMD=-0.57,95%CI=-0.72-0.42),and with serum vitamin E level detection using high performance liquid chromatography (HPLC)(SMD=-0.41,95%CI=-0.59-0.24)and using method other than HPLC (SMD=-0.67,95%CI=-0.91-0.43)(all P<0.001).Sensitivity analysis and publication bias test showed that the results of the study were stable and there was no publication bias for the literatures included in the study.Conclusion Serum vitamin E level is low in esophageal cancer patients.