| 吴茱萸汤颗粒剂、配方颗粒剂及传统汤剂中指标成分的含量比较 |
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| 引用本文： | 林伟雄,乐智勇,车海燕,刘荫贞,刘冲,王晖. 吴茱萸汤颗粒剂、配方颗粒剂及传统汤剂中指标成分的含量比较[J]. 中国实验方剂学杂志, 2017, 23(13): 30-34 |
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| 作者姓名： | 林伟雄 乐智勇 车海燕 刘荫贞 刘冲 王晖 |
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| 作者单位： | 广东药科大学, 广州 510006,康美(北京)药物研究院有限公司, 北京 102629,康美(北京)药物研究院有限公司, 北京 102629,广东药科大学, 广州 510006,广东药科大学, 广州 510006,广东药科大学, 广州 510006 |
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| 基金项目： | 广东省战略性新兴产业区域集聚发展试点项目（2014793） |
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| 摘 要： | 目的:比较吴茱萸汤颗粒剂、配方颗粒剂与传统汤剂中指标性成分的含量差异。方法:采用不同高效液相色谱法(HPLC)测定吴茱萸颗粒剂、配方颗粒剂与传统汤剂中吴茱萸碱、吴茱萸次碱、人参皂苷Re和人参皂苷Rb1的含量,并对含量测定方法进行考察。结果:颗粒剂、配方颗粒剂与传统汤剂中吴茱萸碱和吴茱萸次碱质量浓度之和分别为47.32,13.49,12.60 mg·L~(-1),颗粒剂、配方颗粒剂中二者的质量浓度之和分别为传统汤剂的3.76,1.07倍;人参皂苷Re和人参皂苷Rb1质量浓度之和分别为335.23,345.28,307.39 mg·L~(-1)。颗粒剂、配方颗粒剂中二者的质量浓度之和分别为传统汤剂的1.09,1.12倍。结论:比较吴茱萸碱和吴茱萸次碱的含量时,颗粒剂与传统汤剂相差较大,而配方颗粒剂与传统汤剂基本一致;比较人参皂苷Re和人参皂苷Rb1的含量时,颗粒剂、配方颗粒剂与传统汤剂基本一致。
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| 关 键 词： | 吴茱萸汤 颗粒剂 配方颗粒 汤剂 吴茱萸碱 吴茱萸次碱 人参皂苷类 |
| 收稿时间： | 2017-01-05 |
Comparison of Contents of Index Components in Granule,Dispensing Granule and Traditional Decoction of Wuzhuyu Tang |
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| LIN Wei-xiong,LE Zhi-yong,CHE Hai-yan,LIU Yin-zhen,LIU Chong and WANG Hui. Comparison of Contents of Index Components in Granule,Dispensing Granule and Traditional Decoction of Wuzhuyu Tang[J]. China Journal of Experimental Traditional Medical Formulae, 2017, 23(13): 30-34 |
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| Authors: | LIN Wei-xiong LE Zhi-yong CHE Hai-yan LIU Yin-zhen LIU Chong WANG Hui |
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| Affiliation: | Guangdong Pharmaceutical University, Guangzhou 510006, China,Kangmei (Beijing) Pharmaceutical Research Institute Co. Ltd., Beijing 102629, China,Kangmei (Beijing) Pharmaceutical Research Institute Co. Ltd., Beijing 102629, China,Guangdong Pharmaceutical University, Guangzhou 510006, China,Guangdong Pharmaceutical University, Guangzhou 510006, China and Guangdong Pharmaceutical University, Guangzhou 510006, China |
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| Abstract: | Objective: To compare the contents of index components in granule,dispensing granule and traditional decoction of Wuzhuyu Tang. Method: The contents of evodiamine,rutaecarpine,ginsenoside Re and ginsenoside Rb1 in these three forms of Wuzhuyu Tang were determined by HPLC. Result: The total contents of evodiamine and rutaecarpine in granule,dispensing granule and traditional decoction of Wuzhuyu Tang were 47.32,13.49,12.60 mg·L-1,the total contents of ginsenoside Re and ginsenoside Rb1 in these three forms of Wuzhuyu Tang were 335.23,345.28,307.39 mg·L-1. Conclusion: The granule is obviously different from the traditional decoction in terms of the content of evodiamine and rutaecarpine,while other index component are basically identical. |
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| Keywords: | Wuzhuyu Tang granules dispensing granule decoction evodiamine rutaecarpine ginsenosides |
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