多黏菌素B局部给药治疗泛耐药鲍曼不动杆菌神经系统感染

目的：探讨泛耐药鲍曼不动杆菌神经系统感染的治疗策略,为该类疾病的临床治疗提供参考和借鉴。方法：结合临床药师亲身参与的一例泛耐药鲍曼不动杆菌神经系统感染的治疗,介绍多粘菌素B在治疗中的合理应用。结果：临床药师根据相关“共识”意见,推荐通过多粘菌素B局部给药方式,加强局部组织药物浓度,提高泛耐药鲍曼不动杆菌治疗效果。同时,在多粘菌素B的应用剂量、途径、监护等多方面为临床提供了合理建议。最终,患者感染得以控制,未出现肾毒性和神经毒性反应。结论：多粘菌素B的局部用药为泛耐药鲍曼不动杆菌神经系统感染治疗提供了新思路。临床药师在药物的合理应用中应当发挥重要作用。

Effect of Using Polymyxin B by Local Medication on Xdr-Acinetobacter Baumannii Infections of the Nervous System

OBJECTIVE To discuss extensively drug resistant(XDR)-Acinetobacter baumannii infection treatment strategy of the nervous system. METHODS Combining with a case of XDR-Acinetobacter baumannii therapy of nervous system infection, to introduce reasonable application of polymyxin B. RESULTS According to the consensus, the clinical pharmacist recommended to use polymyxin B by local medication to strengthen the local tissue drug concentration and improve the effect of XDR-Acinetobacter baumannii treatment. At the same time, the clinical pharmacist provided the reasonable suggestions in many aspects, such as in the application of polymyxin B dosage, ways, monitoring and so on for clinician. In the end, the infection was under control without renal toxicity and nerve toxicity reaction. CONCLUSION Using polymyxin B by local medication provides a new way of thinking of XDR-Acinetobacter baumannii infections of the nervous system.