| 钩藤与天麻配伍前后异钩藤碱在SHR大鼠肝脏和肾脏的分布 |
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| 引用本文： | 张卫国,李晓倩,王兴,王萍,王敏智,李莹.钩藤与天麻配伍前后异钩藤碱在SHR大鼠肝脏和肾脏的分布[J].中国实验方剂学杂志,2011,17(7):220-223. |
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| 作者姓名： | 张卫国 李晓倩 王兴 王萍 王敏智 李莹 |
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| 作者单位： | 西南交通大学生命科学与工程学院,成都,610031 |
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| 基金项目： | 国家自然科学基金项目，中央高校基本科研业务会专项资金 |
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| 摘 要： | 目的:观察钩藤与天麻配伍前后异构藤碱在SHR大鼠肝脏和肾脏的分布变化,探讨药物配伍前后对其归经的影响。方法:采用原发性高血压大鼠(SHR),钩藤组给予钩藤水煎液,天麻钩藤组给予钩藤天麻配伍后水煎液,空白组给予生理盐水,给药剂量为1.172 g.kg-1,用高效液相色谱法测定钩藤与天麻配伍前后其效应成分异钩藤碱在SHR大鼠肝脏和肾脏中的含量;色谱条件:色谱柱:WatersTM(4.6 mm×250 mm,RP 18.5μm);流动相甲醇-水(70∶30)pH 8.0;流速为0.8 mL.min-1,检测波长254 nm;柱温30℃;进样量20μL。结果:异钩藤碱对照品在肝脏和肾脏组织中在0.08～16.0 mg.L-1具有较好的线性关系;钩藤与天麻配伍前后在肝脏和肾脏的异钩藤碱的分布具有显著的差异性(P<0.05)。结论:中药配伍与归经之间有着密切的相关性。
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| 关 键 词： | 钩藤 天麻 配伍 归经 异钩藤碱 分布 |
| 收稿时间： | 2010/10/14 0:00:00 |
Distribution of Isorhynchophyline in Liver and Kidney of SHR Rats before and after Compatiblity of Unicariae Ramulus Cum Uncis with Gastrodiae Rhizoma |
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| ZHANG Wei-guo,LI Xiao-qian,WANG Xing,WANG Ping,WANG Min-zhi and LI Ying.Distribution of Isorhynchophyline in Liver and Kidney of SHR Rats before and after Compatiblity of Unicariae Ramulus Cum Uncis with Gastrodiae Rhizoma[J].China Journal of Experimental Traditional Medical Formulae,2011,17(7):220-223. |
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| Authors: | ZHANG Wei-guo LI Xiao-qian WANG Xing WANG Ping WANG Min-zhi and LI Ying |
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| Institution: | School of Life Science and Engineering, Southwest Jiao-Tong University, Chengdu 610031, China;School of Life Science and Engineering, Southwest Jiao-Tong University, Chengdu 610031, China;School of Life Science and Engineering, Southwest Jiao-Tong University, Chengdu 610031, China;School of Life Science and Engineering, Southwest Jiao-Tong University, Chengdu 610031, China;School of Life Science and Engineering, Southwest Jiao-Tong University, Chengdu 610031, China;School of Life Science and Engineering, Southwest Jiao-Tong University, Chengdu 610031, China |
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| Abstract: | Objective:To study the distribution of isorhynchophyline in liver and kidney tissues of SHR rats before and after compatibility of Gastrodiae Rhizoma with Unicariae Ramulus Cum Unics Le,to investigate the impact of channel tropism before and after combination.Method:Uncariae Ramulus Cum Uncis decoction group was administrated Uncariae Ramulus Cum Unics,Tianma Gouteng decoction group was administrated with decoction of compatible Gastrodiae Rhizoma with Unicariae Ramulus Cum Uncis at a dose of 1.172 g.kg-1.A... |
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| Keywords: | Unicariae Ramulus Cum Uncis Gastrodiae Rhizoma compatibility channel tropism isorhynchophyline distribution |
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