黄芩苷对连翘苷在家兔体内药动学的影响

目的:探讨连翘苷及与黄芩苷配伍后静脉推注给药在家兔体内的药代动力学规律。方法:兔子10只,随机分为2组,Ⅰ组耳缘静脉推注连翘苷溶液1 mg.kg-1。Ⅱ组耳缘静脉推注连翘苷1 mg.kg-1和黄芩苷90 mg.kg-1,HPLC测定血浆中的连翘苷的药物浓度,kinetic软件求算其动力学参数,并进行统计学分析。结果:静脉给药后,连翘苷血药浓度的回归方程为Y=0.000 1X-2.933 6(r=0.997 3),连翘苷在1.016～254 mg.L-1线性关系良好。非房室模型拟合后,单用和复合给药得到的连翘苷的主要药动学参数如药时曲线下面积AUC(0-∞)、平均滞留时间MRT(0-∞)、最大血药浓度Cmax、半衰期T1/2、超半峰浓度时间HVD等均有显著差异。结论:黄芩苷能够影响连翘苷在家兔体内的药动学过程。

Effect of Baicalin on Pharmacokinetics of Phillyrin in Rabbits

Objective: To investigate the pharmacokinetics of phillyrin and phillyrin-baicalin compound after intravenous injection (iv)in rabbits. Method: Ten rabbits were randomly divided into two groups.One group was administered with phillyrin (1 mg ·kg^-1)by iv,while the other were treated with phillyrin (1 mg ·kg^-1)-baicalin (90 mg ·kg^-1)compound by iv.The concentration of CA in plasma was determined by HPLC.The key parameters of pharmacokinetics were calculated and anylyzed by kinetic software.The calibration curve was linear (r=0.997 3)in the range of 1.016-254 mg ·L^-1. Result: Concentration-time courses of phillyrin alone and phillyrin-baicalin compound were consistent with non-compartment model after iv.The key pharmacokinetic parameters of phillyrin alone were different with that of phillyrin-baicalin compound (P<0.05). Conclusion: Baicalin can affect the pharmacokinetics of constituent phillyrin in rabbits.