| 伤科喷雾剂中士的宁的体外透皮吸收 |
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| 引用本文： | 吕佳,袁子民,张振秋,叶焕.伤科喷雾剂中士的宁的体外透皮吸收[J].中国实验方剂学杂志,2011,17(8):15-17. |
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| 作者姓名： | 吕佳 袁子民 张振秋 叶焕 |
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| 作者单位： | 辽宁中医药大学药学院,辽宁,大连,116600 |
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| 基金项目： | 辽宁省教育厅青年基金计划A课题 |
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| 摘 要： | 目的:研究伤科喷雾剂中士的宁的透皮吸收特性。方法:采用SD大鼠腹部离体皮肤为渗透屏障,体外透皮吸收,采用Franz扩散池进行体外扩散试验,HPLC检测定士的宁的含量。结果:伤科喷雾剂中士的宁可以透过大鼠腹部皮肤,稳态渗透速率J=0.015 3 mg·cm-2·h-1,时滞Tlag=0.235 h。结论:本实验可为伤科喷雾剂的制备工艺研究提供科学的依据。
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| 关 键 词： | 伤科喷雾剂 士的宁 透皮吸收 |
| 收稿时间： | 2010/12/6 0:00:00 |
Study of Percutaneous Absorption of Strychnine in Shangke Sprays in vitro |
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| LU Ji,YUAN Zi-min,ZHANG Zhen-qiu and YE Huan.Study of Percutaneous Absorption of Strychnine in Shangke Sprays in vitro[J].China Journal of Experimental Traditional Medical Formulae,2011,17(8):15-17. |
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| Authors: | LU Ji YUAN Zi-min ZHANG Zhen-qiu and YE Huan |
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| Institution: | College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China;College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China;College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China;College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China |
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| Abstract: | Objective:
To study the percutaneous absorption of strychnine in Shangke spray in vitro. Method: The transdermal permeation tests of strychnine in Shangke sprays were performed through excised rats skin in Franz diffusion cells. Strychnine concentration was determined by HPLC. Result: Strychnine can penetrate through rat skin. The permeation rate and the lag time were 0.015 3 mg ·cm-2 ·h-1 and 0.235 h respectively. Conclusion: The research provides experimental data for the design of Shangke sprays. |
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| Keywords: | Shangke sprays strychnine percutaneous absorption |
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