芪参健骨颗粒抗炎镇痛作用的研究

目的:观察芪参健骨颗粒的抗炎镇痛作用。方法:将小鼠分为模型对照组,芪参健骨颗粒低、中、高剂量给药组和阳性对照双氯芬酸钠组,ig给药剂量分别为22.5,45,90,0.009 g.kg-1,观察药物对二甲苯所致小鼠耳廓肿胀的影响。将大鼠分为模型对照组,芪参健骨颗粒低、中、高剂量给药组和阳性对照双氯芬酸钠组,ig给药剂量分别为15,30,60,0.006 g.kg-1,观察药物对蛋清所致足跖肿胀影响。以此考察芪参健骨颗粒的抗炎作用;采用小鼠热板法和小鼠醋酸扭体实验(分组、给药剂量同耳廓肿胀实验),考察芪参健骨颗粒的镇痛作用。结果:芪参健骨颗粒3个剂量组和双氯芬酸钠组ig给药能有效防治二甲苯所致的小鼠耳廓肿胀(抑制率分别为13%,12%,16%,28%)和10%蛋清所致的大鼠足跖肿胀(中剂量效果最佳);能有效抑制小鼠热板和乙酸所致的疼痛(抑制率分别为18%,39%,93%,73%;12%,25%,48%,79%),并呈现一定的剂量相关性。结论:芪参健骨颗粒对急性炎症反应、热刺激和乙酸致痛有明显的抑制作用。

Anti-inflammatory and Analgesic Efects of Qishen Jiangu Granule

Objective: To study the anti-inflammatory and analgesic effects of Qishen Jiangu Granule. Method: Models of xylene-induced mice ear edema,albumin-induced rats paw edema were performed to study the anti-inflammatory effect.Acetic acid-induced writhing and hot-plate test in mice were used to study the analgeic effect. Result: The inhibitory rates of low,medium and high dose of Qishen Jiangu Granule on mice ear edema were 13%,12%,and 16% respectively.Albumin-induced rat paw edema were significantly suppressed by Qishen Jiangu Granule (the medium dose was the optimum one).The writhing time of mice induced by hot plate and acetic acid-induced writhing were remarkably improved in a dose-dependent manner.(The inhibitory rate of which were 18%,39%,93%,73% and 12%,25%,48%,79%). Conclusion: Qishen Jiangu Granule has obvious anti-inflammatory and pain-relieving effect.