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| 海金护卫散微粉对小鼠抗炎及镇痛作用 | |
| 引用本文： | 闫荟,孙晓迪,刘守成,孙世光,张卫东,杨锋,史琪荣,谢予朋,刘爽.海金护卫散微粉对小鼠抗炎及镇痛作用[J].中国实验方剂学杂志,2011,17(4):157-159. |
| 作者姓名： | 闫荟 孙晓迪 刘守成 孙世光 张卫东 杨锋 史琪荣 谢予朋 刘爽 |
| 作者单位： | 1. 北京军区总医院药剂科,北京,100700 2. 中国人民解放军第二六六医院药剂科,河北,承德,067000 3. 北京军区司令部第二离职干部休养所,北京,100093 |
| 摘 要： | 目的:考察海金护卫散微粉对小鼠的抗炎及镇痛效果。方法:实验小鼠分为6组:空白组,阿司匹林(1.4 g.kg-1)组,海金护卫散普通粉(1.5 g.kg-1),海金护卫散微粉(4.5,3.0,1.5 g.kg-1)组,连续ig 7 d,采用二甲苯致小鼠耳廓肿胀法观察抗炎作用;采用热板法和扭体法观察对小鼠的镇痛作用。结果:海金护卫散微粉对二甲苯所致小鼠耳廓肿胀的抑制作用明显,呈现出随剂量增加而增强的趋势。与海金护卫散普通粉相当;与阿司匹林相当。海金护卫散微粉能使小鼠痛阈值提高,舔足次数减少;使小鼠扭体潜伏期延长,扭体次数减少。表明海金护卫散微粉具有明显的镇痛作用,与海金护卫散普通粉相当。结论:海金护卫散微粉对小鼠具有抗炎镇痛作用。 |
| 关 键 词： | 海金护卫散微粉 抗炎 镇痛 |
| 收稿时间： | 2010/8/31 0:00:00 |
Anti-inflammatory and Analgesic Activity of Haijin Huwei San Micro-powder in Mice |
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| YAN Hui,SUN Xiao-di,LIU Shou-cheng,SUN Shi-guang,ZHANG Wei-dong,YANG Feng,SHI Qi-rong,XIE Yu-peng and LIU Shuang.Anti-inflammatory and Analgesic Activity of Haijin Huwei San Micro-powder in Mice[J].China Journal of Experimental Traditional Medical Formulae,2011,17(4):157-159. | |
| Authors: | YAN Hui SUN Xiao-di LIU Shou-cheng SUN Shi-guang ZHANG Wei-dong YANG Feng SHI Qi-rong XIE Yu-peng and LIU Shuang |
| Institution: | Department of pharmacy,The General Hospital of Beijing Military Region,Beijing 100700,China;Department of pharmacy,The General Hospital of Beijing Military Region,Beijing 100700,China;Department of pharmacy,The No 266 Hospital of PLA,Chengde 067000,China;Department of pharmacy,The General Hospital of Beijing Military Region,Beijing 100700,China;Department of pharmacy,The General Hospital of Beijing Military Region,Beijing 100700,China;Department of pharmacy,The General Hospital of Beijing Military Region,Beijing 100700,China;Department of pharmacy,The General Hospital of Beijing Military Region,Beijing 100700,China;Department of pharmacy,The General Hospital of Beijing Military Region,Beijing 100700,China;The Second Cadres Sanatorium,Beijing Military Command,Beijing 100093,China |
| Abstract: | Objective:To observe anti-inflammatory and analgesic activity in mice of Haijin Huwei San mi-cro-powder.Method: The model of xylene-induced auricular swelling in mice was used to observe the anti-inflam-matory effects.Analgesic effect of Haijin Huwei San micro-powder was investigated by hot plate test and acetic acid writhing test in mice.Result: Haijin Huwei San micro-powder could reduce the degree of tumefaction in auricle,with dose-dependent manner.Could reach the similar effect compared with Haijin Huwe... |
| Keywords: | Haijin Huwei San micro-powder anti-inflammation analgesic |
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