|
|||||
|
|
| 雷公藤肝毒性及其作用机制的研究进展 | |
| 引用本文： | 柴智,周文静,高丽,王永辉,樊慧杰,周然.雷公藤肝毒性及其作用机制的研究进展[J].中国实验方剂学杂志,2011,17(7):243-246. |
| 作者姓名： | 柴智 周文静 高丽 王永辉 樊慧杰 周然 |
| 作者单位： | 1. 湖北中医药大学,武汉,430065;山西中医学院,太原,030024 2. 山西省中医药研究院,太原,030012 3. 山西中医学院,太原,030024 |
| 基金项目： | 国家自然科学基金面上项目 |
| 摘 要： | 雷公藤系卫矛科雷公藤属木质藤本植物,化学成分复杂,具有多种药理作用,临床应用广泛且疗效显著,但其引起肝毒性的报道也时有发生,因此作者从雷公藤引起肝毒性的物质基础、临床特点、病理学基础以及肝毒性发生的作用机制几个方面进行综述,以便为雷公藤临床安全用药和科学研究提供更多的依据和方法。 |
| 关 键 词： | 雷公藤 肝毒性 物质基础 作用机制 |
| 收稿时间： | 2010/11/11 0:00:00 |
Experimental Progress of Liver Toxicity of Tripterygium wilfordii and Its Mechanism 3* |
|
| CHAI Zhi,ZHOU Wen-jing,GAO Li,WANG Yong-hui,FAN Hui-jie and ZHOU Ran.Experimental Progress of Liver Toxicity of Tripterygium wilfordii and Its Mechanism 3*[J].China Journal of Experimental Traditional Medical Formulae,2011,17(7):243-246. | |
| Authors: | CHAI Zhi ZHOU Wen-jing GAO Li WANG Yong-hui FAN Hui-jie and ZHOU Ran |
| Institution: | Hubei University of Traditional Chinese Medicine, Wuhan 430065, China; Shanxi College of Traditional Chinese Medicine, Taiyuan 030024, China;Shanxi Institute of Chinese Medicine, Taiyuan 030012, China;Shanxi College of Traditional Chinese Medicine, Taiyuan 030024, China;Shanxi College of Traditional Chinese Medicine, Taiyuan 030024, China;Shanxi College of Traditional Chinese Medicine, Taiyuan 030024, China;Shanxi College of Traditional Chinese Medicine, Taiyuan 030024, China |
| Abstract: | Tripterygium wilfordii Hook. f. (TWHF) belongs to Celastraceae. It is a traditional Chinese medicine, with complex chemical constituents and a variety of pharmacological effects. And it is applied for many diseases with significant effects. But the liver toxicity events caused by TWHF were often reported. Liver toxicity caused by TWHF were reviewed in this paper from four aspects including material basis, clinical features, pathological basis and mechanism, in order to provide more reference and methods for clinical safety and scientific research. |
| Keywords: | Tripterygium wilfordii liver toxicity material basis mechanism |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
| 点击此处可从《中国实验方剂学杂志》浏览原始摘要信息 | |
| 点击此处可从《中国实验方剂学杂志》下载免费的PDF全文 | |