Influence of cefoperazone and azithromycin on the pharmacokinetics of pazufloxacin in rats. |
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Authors: | Sheng Lou Wei Li Qin Hu |
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Institution: | School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China. |
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Abstract: | The effects of cefoperazone and azithromycin administered separately on the pharmacokinetics of pazufloxacin (PZFX) mesilate were investigated in rats. Animals were injected with cefoperazone at a high dose (180 mg/kg) or azithromycin at a dose of 45 mg/kg through the tail vein 10 min before intravenous (i.v.) administration of PZFX (45 mg/kg). Blood concentrations of PZFX were determined by HPLC. Parameters relating to the pharmacokinetic interaction between PZFX and cefoperazone or azithromycin were estimated by a two-compartmental model. The experimental results showed that the presence of azithromycin significantly delayed the t(1/2 beta) and mean residence time (MRT) of PZFX in the plasma. However, no significant changes between the control group and the cefoperazone-treated animals in the pharmacokinetic parameters of PZFX, such as t(1/2 beta), volume of distribution (Vd), area under the curve (AUC) and the clearance (Cl) were observed. |
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