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The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease |
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| Authors: | Marissa Penna-Martinez Elizabeth Ramos-Lopez Inka Robbers Heinrich Kahles Stefanie Hahner Holger Willenberg Nicole Reisch Christian Seidl Maria Segni Klaus Badenhoop |
| Affiliation: | (1) Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Hospital Frankfurt, Frankfurt am Main, Germany;(2) Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital Wuerzburg, Wuerzburg, Germany;(3) Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany;(4) Department of Internal Medicine, Division of Endocrinology and Diabetes, University Hospital Munich, Munich, Germany;(5) Department of Transplantation Immunology, Institute of Transfusion Medicine and Immunohaematology, Red Cross Blood Donor Service, Frankfurt am Main, Germany;(6) Department of Pediatrics Endocrinology Unit, University "La Sapienza," Rome, Italy |
| Abstract: | BackgroundThree genes have been confirmed as major joint susceptibility genes for endocrine autoimmune disease:human leukocyte antigen class II, cytotoxic T-lymphocyte antigen 4 and protein tyrosine phosphatase non-receptor type 22. Recent studies showed that a genetic variation within the interferon induced helicase domain 1 (IFIH1) locus (rs1990760 polymorphism) is an additional risk factor in type 1 diabetes and Graves' disease (GD). |
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