| 山醇提取物治疗实验性脑梗塞 |
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| 引用本文： | 秦新月,王伟,董为伟. 山醇提取物治疗实验性脑梗塞[J]. 卒中与神经疾病, 1997, 0(2) |
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| 作者姓名： | 秦新月 王伟 董为伟 |
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| 作者单位： | 重庆医科大学临床医学院神经内科神经病学研究所，同济医科大学 |
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| 摘 要： | 采用光化学诱导法建立Ｗｉｓｔａｒ鼠大脑中动脉闭塞脑缺血模型，应用具有强力血小板活化因子（ＰＡＦ）受体拮抗作用的中药山醇提取物治疗实验性脑梗塞，通过局部脑血流量（ｒＣＢＦ）、脑组织含水量、血浆粘度及脑组织超微结构改变等指标观察，发现山醇能改善缺血区脑组织的ＣＢＦ，减轻脑水肿，降低血浆粘度，减轻缺血后神经元线粒体的肿胀，减少核的坏死溶解，具有一定的脑保护作用
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| 关 键 词： | 脑缺血模型 血小板活化因子 鼠 |
Treatment of experimental cerebral infarction by alcoholic extract of piper hancei (PHE) |
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| Qin Xinyue,Wan Wei,Dong Weiwei. Departmeunt of Neurology,Chongqing Medical University,Chongqing. Treatment of experimental cerebral infarction by alcoholic extract of piper hancei (PHE)[J]. Stroke and Nervous Diseases, 1997, 0(2) |
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| Authors: | Qin Xinyue Wan Wei Dong Weiwei. Departmeunt of Neurology Chongqing Medical University Chongqing |
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| Affiliation: | Qin Xinyue,Wan Wei,Dong Weiwei. Departmeunt of Neurology,Chongqing Medical University,Chongqing,630042 |
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| Abstract: | Alcoholic extract of Piper hancei(PHE) which is of a role of Plateiet activation factor receptor antagonist was applied to treat the experiment rat cerebral ischemia induced by photochemical occlusion of middle cerebral artery. The results showed that the PHE could elevate the rCBF in ischemic region, reduce the cerebral edema and the plasma viscosity, and relieve the ischemic neuronal necrosis. The authors suggested that the PHE had an effect on cerebral protection in experimental cerebral infarction. |
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| Keywords: | Piper hancei Platelet activating factor Rat Cerebral ischemia model |
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