Cortical inhibition in Parkinson's disease: new insights from early, untreated patients |
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| Authors: | Cantello R Tarletti R Varrasi C Cecchin M Monaco F |
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| Affiliation: | Department of Clinical and Experimental Medicine, Section of Neurology, Università del Piemonte Orientale A. Avogadro, Via Solaroli 17, 28100 Novara, Italy. cantello@med.unipmn.it |
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| Abstract: | Transcranial magnetic stimulation (TMS) has opened important perspectives on the pathophysiological bases and potential targets of treatment strategies for idiopathic Parkinson’s disease (IPD). Studies have been mainly focusing on motor cortical inhibitory phenomena. However, differences in patients and methods caused several discrepancies, particularly on the so-called long-latency cortical inhibition (LICI). We wanted to challenge such controversies by studying early, drug-naïve patients, and by reproducing the original method that detected a pathologic LICI in IPD. |
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| Keywords: | Parkinson’s disease transcranial magnetic stimulation motor cortex cortical inhibition cortical silent period |
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