Circulating oxidized lipoproteins and cardiovascular risk |
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Authors: | Hiroyuki Itabe |
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Institution: | (1) Department of Biological Chemistry, Showa University School of Pharmaceutical Sciences, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan |
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Abstract: | It has been widely recognized that oxidized low-density lipoprotein (oxLDL) is involved in cardiovascular diseases. However,
one of the major questions has been whether oxLDL is a cause or a result of atherosclerotic lesion development. Immunologic
detection of human circulating oxLDL has been established, and evidence of a close relationship between oxLDL levels in human
circulating plasma and cardiovascular diseases has been accumulating. Recent prospective studies suggest that plasma oxLDL
measurement is potentially a predictive marker for cardiovascular diseases. Another question has been how LDL is oxidized
in vivo. Recent progress in structural studies has shown evidence that oxLDL in vivo is oxidized differently from copper-induced
oxLDL. |
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Keywords: | |
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