| 注射用氟康唑的制备工艺及稳定性研究 |
| |
| 引用本文： | 付桂英,郭晓华,赵颖,杨珺,吴坤.注射用氟康唑的制备工艺及稳定性研究[J].中国药房,2005,16(11):832-834. |
| |
| 作者姓名： | 付桂英 郭晓华 赵颖 杨珺 吴坤 |
| |
| 作者单位： | 解放军307医院,北京市,100039 |
| |
| 摘 要： | 目的:筛选注射用氟康唑的制备工艺,建立其含量测定方法。方法:以pH值及助溶剂种类等为考察因素筛选处方;采用高效液相色谱法测定其含量。结果:溶液pH在6.5～8.5时制剂稳定性较好,且丙二醇可增加制剂澄明度;氟康唑检测浓度在40～200μg/ml范围内线性关系良好,平均回收率为100.37%,RSD=1.37%(n=3)。结论:按照筛选出的处方、工艺制备的注射用氟康唑质量稳定,含量测定方法准确、可行。
|
| 关 键 词： | 注射用氟康唑 制备工艺 含量测定 |
| 文章编号： | 1001-0408(2005)11-0832-03 |
| 修稿时间： | 2004年11月2日 |
Preparation Technique of Fluconazole for Injection and Its Stability Study |
| |
| FU Guiying,Guo Xiaohua,ZHAO Ying,YANG Jun,WU Kun.Preparation Technique of Fluconazole for Injection and Its Stability Study[J].China Pharmacy,2005,16(11):832-834. |
| |
| Authors: | FU Guiying Guo Xiaohua ZHAO Ying YANG Jun WU Kun |
| |
| Abstract: | OBJECTIVE:To select a technique for preparation of fluconazole for injection and to establish a method for determination of its content.METHODS:The formula was selected on the basis of pH value and species of solution adjuvant.The content was determined by HPLC.RESULTS:The preparation was stable when pH value was between6.5～8.5,and its clarity could be increased by propylene glycol.The detectable concentration of fluconazole showed a good linear correlation in the range of40～200μg/ml.The average recovery was100.37%,RSD=1.37%(n=3).CONCLUSION:The fluconazole for injection prepared by the present technique is stable in quality and the method for content determination is accurate and practicable. |
| |
| Keywords: | Fluconazole for injection Preparation technique Content determination |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
