Monoamine oxidase inhibitory naphthoquinones from the roots ofLithospermum erythrorhizon |
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Authors: | Woo Hoi Choi Seong Su Hong Seon A Lee Xiang Hua Han Kyong Soon Lee Myung Koo Lee Bang Yeon Hwang Jai Seup Ro |
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Affiliation: | College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea and 2Research Center for Bioresource and Health, Chungbuk National University, Cheongju 361-763, Korea. |
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Abstract: | Activity-guided fractionation of a hexane-soluble extract of the roots of Lithospermum erythrorhizon, using a mouse brain monoamine oxidase (MAO) inhibition assay, led to the isolation of two known naphthoquinones, acetylshikonin and shikonin, and a furylhydroquinone, shikonofuran E. These compounds were shown to inhibit MAO with IC50 values of 10.0, 13.3, and 59.1 microM, respectively. Although no specificity for MAO-A and MAO-B was shown by acetylshikonin and shikonin, a Lineweaver-Burk plot analysis indicated that the inhibition was competitive for both MAO-A and MAO-B activity. |
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Keywords: | Lithospermum erythrorhizon Boraginaceae Naphthoquinone Monoamine oxidase inhibitor |
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