双歧杆菌防治极低出生体重儿坏死性小肠结肠炎的作用研究

目的：观察应用双歧杆菌预防极低出生体重儿坏死性小肠结肠炎（NEC）的有效性。方法：回顾性分析2005年1月～2008年5月在我院NICU住院治疗的生后存活7 d并且开始胃肠道喂养的极低出生体重儿183例的临床资料。结果：预防组NEC发病率为2.10%（2/95）,对照组NEC发生率为11.36%（10/88）,两组比较差异有统计学意义（P〈0.01）。住院期间预防组每日体质量增加（8.108±2.205）g,对照组为（6.256±2.298）g,两组比较差异有统计学意义（P〈0.01）。治疗后7 d两组患儿肠道细菌总数、杆菌、球菌总数及杆球菌比值差异均有统计学意义（P〈0.01）。预防组治疗前、治疗后7 d杆球菌比值差异无统计学意义（P〉0.05）。治疗前两组患儿大便双歧杆菌数的比较差异均无统计学意义（P〉0.05）;治疗后7 d两组患儿大便双歧杆菌数的比较差异有统计学意义（P〈0.01）。预防组治疗前、治疗后7 d大便双歧杆菌数的比较差异有统计学意义（P〈0.01）;对照组治疗前、治疗后7 d大便双歧杆菌数的比较差异无统计学意义（P〉0.05）。结论：给予极低出生体重儿预防性口服双歧杆菌能够降低NEC发病率,促进其体质量增长。其机制与口服双歧杆菌后促进新生儿肠道正常菌群的定植和优势化、维持肠道正常菌群比率有关。

A research on the effect of bifidobacterium in the field of preventing and curing the NEC of very low birth weight children

Objective: To observe the preventing effectiveness of applying bifidobacterium to very low birth weight children with NEC.Methods: The clinical data of 183 patients of NICU hospitalization survival 7 d after birth and fed the gastrointestinal tract of very low birth weight children in our hospital from January 2005 to May 2008 were retrospectively analyzed.Results: From the results,the NEC incidence rate of the preventive group was 2.10%(2/95),while the control group was 11.36%(10/88);the daily weight incre...