原发性胆汁性肝硬化患者46例抗着丝点抗体临床检测分析

目的：研究在原发性胆汁性肝硬化（primary biliary cirrhosis，PBC）患者中，抗着丝点抗体（antieentromere antibody，ACA）与临床表现之间的关系。方法：用间接免疫荧光法检测PBC患者血清抗核抗体（ANA）各荧光模式，比较ACA阳性和阴性患者临床表现的差别和免疫学指标的差别。结果：156例PBC患者中ACA阳性46例（25％），ACA阳性组乏力、黄疸症状少于ACA阴性组，两组问有统计学差异（P〈0．05），肝功能异常症状两组间差异有统计学意义（P〈0．05），ACA阳性组多于ACA阴性组。免疫学指标中，CD4＋和IgM在两组间有统计学意义，ACA阳性组高于阴性组（P〈0．05）。结论：ACA阳性的PBC患者临床表现隐匿，以单纯肝功能异常多见，易造成临床上漏诊。

Detecion of clinical characteristics in 46 patients with primary biliary cirrhosis

Objective: To investige the clinical relationship of anticentromere antibody(ACA) in patients with primary biliary cirrhosis(PBC).Methods: ACA was detected using indirect immunofluorescence(IIF) in 156 patients with PBC,and the difference was compared between the ACA positive and negative gyoup.Results: 46 of the 156 cases in primary biliary cirrhosis were positive,the sensibility was 29%.ACA positive group fatigue,icteric symptoms ACA negative groups,less than there were significant differences between the...