| 灯盏生脉胶囊对脑缺血再灌注损伤大鼠的保护作用 |
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| 引用本文： | 黄一挚,陈朝,黄春晖,陈丹丹. 灯盏生脉胶囊对脑缺血再灌注损伤大鼠的保护作用[J]. 中国医药导报, 2011, 8(9): 55-57 |
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| 作者姓名： | 黄一挚 陈朝 黄春晖 陈丹丹 |
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| 作者单位： | 1. 广西卫生职业技术学院实验中心,广西南宁,530023
2. 广西中医学院第一附属医院药学部,广西南宁,530023 |
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| 摘 要： | 目的：研究灯盏生脉胶囊对脑缺血再灌注损伤的保护作用。方法：将大鼠随机分为假手术组、模型组和灯盏生脉胶囊组。采用改良的Zea Longa线栓法制作大鼠大脑中动脉阻塞模型,缺血后24 h灌胃给予灯盏生脉胶囊,于缺血后7、14、21 d分别测定神经功能缺损评分和体重增长率,于缺血后21 d采用TTC法测定脑梗死体积百分比,免疫组织化学法检测脑组织血管内皮生长因子（VEGF）的表达。结果：与模型组比较,灯盏生脉胶囊组神经功能缺损评分、体重增长率、脑梗死体积百分比及VEGF的表达差异均有统计学意义（均P〈0.05）。结论：灯盏生脉胶囊对大鼠脑缺血再灌注损伤有明显的保护作用,可能与其促进VEGF表达有关。
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| 关 键 词： | 灯盏生脉胶囊 脑缺血再灌注损伤 血管内皮生长因子 |
Protective effects of Dengzhan Shengmai Capsules on focal cerebral ischemia reperfusion injury of rats |
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| HUANG Yizhi,CHEN Chao,HUANG Chunhui,CHEN Dandan. Protective effects of Dengzhan Shengmai Capsules on focal cerebral ischemia reperfusion injury of rats[J]. China Medical Herald, 2011, 8(9): 55-57 |
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| Authors: | HUANG Yizhi CHEN Chao HUANG Chunhui CHEN Dandan |
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| Affiliation: | HUANG Yizhi1,CHEN Chao2,HUANG Chunhui1,CHEN Dandan1 1.Laboratory Centre of Guangxi Health College,Nanning 530023,China,2.Department of Pharmacy,First Clinic Affiliated Hospital to Guangxi Traditional Chinese Medicine |
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| Abstract: | Objective:To investigate the protection of Dengzhan Shengmai Capsules on ischemia reperfusion injury of rats.Methods:Rats were divided into 3 groups in random:sham operation group,model group,Dengzhan Shengmai Capsules group.Middle cerebral artery occlusion(MCAO) model was established according to Zea Longa's pattern.Rats were fed with Dengzhan Shengmai by intragastric administration after 24 h of ischemia.The body growth rate and neuroethology function of rats were tested on 7 d,14 d and 21 d.Cerebral infa... |
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| Keywords: | Dengzhan Shengmai Capsules Cerebral ischemia reperfusion injury Vascular endothelial growth |
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