可溶性甲壳素/海藻酸钠交联微球的制备及其表征和控释性能考察

目的制备可溶性甲壳素/海藻酸钠交联微球，表征微球的微观结构和形态。方法利用滴入法制备可溶性甲壳素/海藻酸钠交联微球，用红外光谱和扫描电镜表征微球的微观结构和形态，以牛血清蛋白为药物模型，研究微球的药物缓释性能。结果可溶性甲壳素与海藻酸钠进行了良好的混溶，并且在钙离子（Ca2+）溶剂环境下形成交联微球。该微球对药物的包封率及缓释性能与海藻酸钠微球相比都有较大改善，包封率从42%提高到74%，药物缓释时间从4 h上升到24 h。结论可溶性甲壳素/海藻酸钠微球的释药具有pH响应性，在pH为1.2的条件下释药慢，而在pH为7.0～7.4时释药快，可用于小肠或结肠定位缓释系统。

Characterization and Drug Controllable Release of Chitin and Alginate Crosslinked Microspheres

Objective To prepare crosslinked microspheres of chitin/alginate particles and characterize the microstructure and morphology. Methods The crosslinked microspheres of chitosan and sodium alginate mixture were prepared.The microstructure and morphology were detected by using infrared spectroscopy(FTIR)and scanning electron microscopy(SEM).The drug slowly delivery property was studied with bovine serum albumin(BSA)as a drug model. Results It was showed that the chitin/alginate was well mixed and the crosslink...