亚胺培南－西司他丁钠治疗重症细菌感染的临床观察

目的：探讨亚胺培南一西司他丁钠治疗重症细菌感染的临床疗效与安全性。方法：68例重症感染患者随机分为观察组和对照组，每组各34例。在对症处理与支持治疗的基础上，观察组予以亚胺培南一西司他丁钠1．0g，wgtt，q8h～q12h；对照组予以头孢噻肟钠2．0～6．0g，wgtt，q12h。疗程均4～14d，观察临床疗效与病原菌清除情况，监测不良反应。结果：观察组与对照组总有效率分别为88．24％、61．76％，细菌清除率分别为82．35％、59．62％，两组比较差异均有统计学意义（均P〈O．05）；而不良反应发生率比较差异无统计学意义（P〉O．05）。结论：早期使用亚胺培南一西司他丁钠治疗重症感染能迅速清除致病菌，促使病变转归，不良反应少或轻微，可作为早期治疗重症细菌感染的推荐药物。

Clinical observation on treating severe bacterial infection by Imipenem and Cilastatin Sodium

Objective: To explore the clinical efficacy and safety of treating severe bacterial infection by Imipenem and Cilastatin Sodium(IM/CI).Methods: 68 patients with severe infection were randomly divided into two groups,and 34 cases in each group.On the basis of symptomatic treatment and supportive care,patients in observation group were given IM/CI,1.0 g,ivgtt,q8 h-q12 h,yet patients in control group were given Cefotaxime Sodium,2.0-6.0 g,ivgtt,q12 h.Course of treatment was 4-14 d.Researchers were observed cli...