| 丁螺环酮与艾司西酞普兰联合治疗脑卒中后中重度抑郁的临床观察 |
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| 引用本文： | 原富强,马振武,于洪岩.丁螺环酮与艾司西酞普兰联合治疗脑卒中后中重度抑郁的临床观察[J].中国医药导报,2011,8(10):80-81. |
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| 作者姓名： | 原富强 马振武 于洪岩 |
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| 作者单位： | 新乡医学院第二附属医院老年精神科,河南新乡,453002 |
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| 摘 要： | 目的：比较丁螺环酮与艾司西酞普兰联用治疗脑卒中后中重度抑郁与单用艾司西酞普兰治疗的疗效及安全性。方法：选择脑卒中后中重度抑郁患者60例,随机分为两组,各30例。研究组采用丁螺环酮与艾司西酞普兰联合治疗,对照组单用艾司西酞普兰治疗,观察疗程均为8周,定期对患者采用HAMD（24项）抑郁量表与TESS副反应量表进行疗效评估。结果：研究组临床疗效总有效率为93.3%（28/30）,显著优于对照组的63.3%（19/30）（χ2=8.91,P=0.031,P〈0.05）。两组治疗后HAMD评定,治疗第1周开始较治疗前有统计学意义,且一直持续至观察第8周,研究组与对照组比较亦有统计学意义（P〈0.05）。两组治疗期间副反应无统计学意义。结论：艾司西酞普兰联用丁螺环酮治疗脑卒中后抑郁较单用艾司西酞普兰治疗疗效显著,安全性高。
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| 关 键 词： | 脑卒中后抑郁 丁螺环酮 艾司西酞普兰 |
Clinical observation of post-stroke depression by Buspirone combined with Escitalopram |
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| YUAN Fuqiang,MA Zhenwu,YU Hongyan.Clinical observation of post-stroke depression by Buspirone combined with Escitalopram[J].China Medical Herald,2011,8(10):80-81. |
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| Authors: | YUAN Fuqiang MA Zhenwu YU Hongyan |
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| Institution: | YUAN Fuqiang,MA Zhenwu,YU Hongyan Department Senile Psychiatry,The Second Affiliated Hospital of Xinxiang Medical University,He'nan Province,Xinxiang 453002,China |
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| Abstract: | Objective:To compare the effect and safety of Buspirone combined with Escitalopram and Escitalopram used singly in the treatment of post-stroke depression.Methods:Totally the 60 post-stroke depression patients were randomized into control group(n=30),treated with Escitalopram,and study group(n=30),treated by Buspirone combined with Escitalopram.The observation lasted 8 weeks.The therapeutic effect and safety were evaluated by the positive and negative syndrome scale of HAMD(24 items),and treatment emergent ... |
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| Keywords: | Post-stroke depression Buspirone Escitalopram |
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