| 一种类凝血酶制剂的人体药动学研究 |
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| 引用本文： | 沈文彧,邸伟庆,刘宏大,张竞超,牛惠生,李怀芬.一种类凝血酶制剂的人体药动学研究[J].中国医药导报,2011,8(10):59-61. |
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| 作者姓名： | 沈文彧 邸伟庆 刘宏大 张竞超 牛惠生 李怀芬 |
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| 作者单位： | 1. 辽宁诺康生物制药有限责任公司,辽宁沈阳,110171
2. 中国医学科学院放射医学研究所,天津,300000 |
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| 摘 要： | 目的：研究单次静注注射用尖吻蛇毒血凝酶（HCA）的人体药代动力学规律。方法：30例男性健康志愿者随机分组至1 U、2 U、4 U 3个剂量组,每组10例,采用放射免疫分析法对受试血清检测HCA的含量,用DAS软件计算其药代动力学参数。结果：受试者给药后,药-时曲线符合二室模型,主要药代动力学参数：t1/2α为34～55 min;t1/2β为301～351 min;CL分别为0.001 1、0.001 2、0.000 9 L/（min.kg）,Vd分别为1.357 0、0.593 4、0.410 1 L/kg,AUC0-tn分别为16 518.38、22 405.67和29 531.41μU/（min.ml）,呈明显的剂量依赖关系。结论：单次静注注射用HCA体内药代动力学特征符合一级线性动力学二室模型。
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| 关 键 词： | 类凝血酶 药动学 放射免疫分析法 |
Pharmacokinetics of a thrombin-like enzyme injection in chinese healthy volunteers |
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| SHEN Wenyu,DI Weiqing,LIU Hongda,ZHANG Jingchao,NIU Huisheng,LI Huaifen.Pharmacokinetics of a thrombin-like enzyme injection in chinese healthy volunteers[J].China Medical Herald,2011,8(10):59-61. |
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| Authors: | SHEN Wenyu DI Weiqing LIU Hongda ZHANG Jingchao NIU Huisheng LI Huaifen |
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| Institution: | SHEN Wenyu1,DI Weiqing1,LIU Hongda1,ZHANG Jingchao1,NIU Huisheng2,LI Huaifen2 1.Liaoning Nuokang Biological pharmaceutical Limited Liability Company,Shenyang 110171,2.Chinese Academy of Medical Sciences Radiology Institute of Radiological Medicine Research,Tianjin 300000 |
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| Abstract: | Objective:To study the pharmacokinetics of heamocoagulase agkistrodon(HCA) injection after a single dose in chinese healthy volunteers.Methods:30 male healthy volunteers were randomly allocated into three groups,receiving 1 U,2 U,4 U HCA injection,respectively.Every group had ten volunteers.The drug concentration in human serum were determined by radioimmunoassay method,and the pharmacokinetic parameters were calculated by DAS software.Results:The serum concentration-time curve fit the two-compartment model... |
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| Keywords: | Thrombin-like enzyme Pharmacokinetics Radioimmunoasssy |
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