| 丹参及缺血预处理对肝热缺血再灌注损伤的保护作用 |
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| 引用本文： | 陈海颖,张学民,徐国兵,严仲瑜. 丹参及缺血预处理对肝热缺血再灌注损伤的保护作用[J]. 现代实用医学, 2002, 14(4): 172-174 |
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| 作者姓名： | 陈海颖 张学民 徐国兵 严仲瑜 |
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| 作者单位： | 100034,北京大学第一医院 |
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| 摘 要： | 目的 应用Wistar大鼠实验，研究丹参，缺血预处理对肝缺血再灌注损伤的保护作用。方法 以无创血管夹夹闭肝门静脉，肝动脉30min，随后开放血管夹60min，造成肝缺血30min，再灌注60min的模型。然后测定ALT、AST、LDH，丙二醛和过氧化物歧化酶活性并进行病理组织学检查。结果 丹参组及缺血预处理组的实验指标均明显好于肝热缺血再灌注对照组。结论 丹参及缺血预处理对肝热缺血再灌注损伤具有保护作用。
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| 关 键 词： | 丹参 缺血预处理 肝热缺血 再灌注损伤 保护作用 血液供给 预防 控制 中医药治疗 大鼠 |
| 文章编号： | 1671-0800(2002)04-0172-03 |
| 修稿时间： | 2001-12-06 |
Protective effect of Danshen and ischemia preconditioning on liver from warm ischemia-reperfusion injury |
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| CHEN Hai Ying,ZHANG Xue Min,XU Guo Bing,et al.. Protective effect of Danshen and ischemia preconditioning on liver from warm ischemia-reperfusion injury[J]. Modern Practical Medicine, 2002, 14(4): 172-174 |
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| Authors: | CHEN Hai Ying ZHANG Xue Min XU Guo Bing et al. |
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| Affiliation: | CHEN Hai Ying,ZHANG Xue Min,XU Guo Bing,et al. First Clinical Hospital,Beijing University,Beijing 100034,China |
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| Abstract: | Objective To observe the protective effect of Danshen and ischemia preconditioning on liver from warm ischemia reperfusion injury. Methods Hepatic ischemia reperfusion model in 47 Wister rats was made by hepatic veins and artery reperfusion for 60 minutes following hepatic portal vein and artery occlusion for 30 minutes. Alanine transaminase,aspartate transaminase, lactate dehydrogenase, malondialdehyde contents, and superoxide dismutase activity were detected, and pathological examination was made. Results Above experimental data of Danshen treated group and preconditioning group are better than those of ischemia reperfusion control group. Conclusion Danshen and ischemia preconditioning may protect liver from warm ischemia reperfusion injury. |
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| Keywords: | Liver/blood supply Reperfusion injury/prevention and control Danshen/therapeutic application |
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